Improvement in risk prediction of atherosclerotic cardiovascular disease (ASCVD) using
information on the genetic predisposition at an individual level might offer new possibilities …

Abstract Purpose of Review The potential of polygenic risk scores (PRS) to improve
atherosclerotic cardiovascular disease (ASCVD) risk assessment and management has …

Recent discoveries from the past 15 years of human genetic association studies have
provided new insights into the common genetic basis of coronary artery disease and its risk …

Background Polygenic risk scores (PRSs) can stratify populations into cardiovascular
disease (CVD) risk groups. We aimed to quantify the potential advantage of adding …

Cardiovascular disease is the leading contributor to years lost due to disability or premature
death among adults. Current efforts focus on risk prediction and risk factor mitigation ‚which …

Cardiometabolic diseases contribute more to global morbidity and mortality than any other
group of disorders. Polygenic risk scores (PRSs), the weighted summation of individually …

An individual's susceptibility to atherosclerotic cardiovascular disease is influenced by
numerous clinical and lifestyle factors, motivating the multifaceted approaches currently …

A polygenic risk score (PRS) is derived from a genome-wide association study and
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …

PRSs for CAD may soon be incorporated into clinical practice. Therefore, there is an urgent
need to establish both analytical and clinical reporting standards for PRSs, and for validating …

Aims Many studies have investigated associations between polygenic risk scores (PRS) and
the incidence of cardiovascular disease (CVD); few have examined whether risk factor …