Microbial pathogens including Enterobacteriaceae family members bear different antibiotic
resistance genes comprising Extended-Spectrum-ß-Lactamases (ESBLs) and Metallo-ß …

ABSTRACT Metallo-β-lactamases (MBLs) are enzymes that hydrolyze β-lactam antibiotics,
resulting in bacterial resistance to these drugs. These proteins have caused concerns due to …

The β-lactams are the most successful class of antibiotic drugs but they are vulnerable to
inactivation by a growing cadre of β-lactamases that now number more than a thousand …

After more than 80 years of development, β‐lactam drugs have become the most widely
used high‐efficiency, low‐toxic broad‐spectrum antibacterial drugs. However, with the …

Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …

The global overuse of antibiotics has led to the emergence of drug-resistant pathogenic
bacteria. Bacteria can combat β-lactams by expressing β-lactamases. Inhibitors of one class …

The development of broad-spectrum metallo-β-lactamase (MBL) inhibitors is challenging
due to structural diversity and differences in metal utilisation by these enzymes. Analysis of …

New Delhi metallo-β-lactamase (NDM-1) is a new metallo-β-lactamase (MBL) that has
recently emerged as a global threat because it confers bacteria with resistance to almost all …

The worldwide proliferation of life-threatening metallo-β-lactamase (MBL)-producing Gram-
negative bacteria is a serious concern to public health. MBLs are compromising the …

Metallo-β-lactamases (MBLs) catalyze the hydrolysis of β-lactams including penicillins,
cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity …