Inflammaging and 'Garb-aging'

C Franceschi, P Garagnani, G Vitale, M Capri… - Trends in Endocrinology …, 2017 - cell.com
'Inflammaging'refers to the chronic, low-grade inflammation that characterizes aging.
Inflammaging is macrophage centered, involves several tissues and organs, including the …

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

C Franceschi, P Garagnani, P Parini… - Nature Reviews …, 2018 - nature.com
Ageing and age-related diseases share some basic mechanistic pillars that largely
converge on inflammation. During ageing, chronic, sterile, low-grade inflammation—called …

[PDF][PDF] Inflammaging 2018: an update and a model

C Franceschi, A Zaikin, S Gordleeva… - Seminars in …, 2018 - discovery.ucl.ac.uk
'Inflammaging'refers to the chronic, low-grade inflammation that characterizes aging. The
conceptualization of inflammaging, resulting from the convergence of studies on the …

Inflammaging as a target for healthy ageing

B Dugan, J Conway, NA Duggal - Age and Ageing, 2023 - academic.oup.com
Life expectancy has been on the rise for the past few decades, but healthy life expectancy
has not kept pace, leading to a global burden of age-associated disorders. Advancing age is …

Understanding how we age: insights into inflammaging

D Baylis, DB Bartlett, HP Patel, HC Roberts - Longevity & healthspan, 2013 - Springer
Inflammaging is characterized by the upregulation of the inflammatory response that occurs
with advancing age; its roots are strongly embedded in evolutionary theory. Inflammaging is …

Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases

C Franceschi, J Campisi - Journals of Gerontology Series A …, 2014 - academic.oup.com
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon
has been termed as “inflammaging.” Inflammaging is a highly significant risk factor for both …

Exploring the complex relations between inflammation and aging (inflamm-aging): anti-inflamm-aging remodelling of inflamm-aging, from robustness to frailty

G Sergio - Inflammation Research, 2008 - Springer
“Inflamm-aging” denotes the up-regulation of certain pro-inflammatory cytokines at older
ages, and associated chronic diseases. It is well known that blood levels of cortisol also …

Inflammation and aging: signaling pathways and intervention therapies

X Li, C Li, W Zhang, Y Wang, P Qian… - Signal Transduction and …, 2023 - nature.com
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Human inflammaging

T Fülöp, A Larbi, JM Witkowski - Gerontology, 2019 - karger.com
Human aging is a very complex process that occurs in an intricate biological and
physiological setting. Many changes occur with aging and among the most important are …

Inflammaging and human longevity in the omics era

D Monti, R Ostan, V Borelli, G Castellani… - Mechanisms of Ageing …, 2017 - Elsevier
Inflammaging is a recent theory of aging originally proposed in 2000 where data and
conceptualizations regarding the aging of the immune system (immunosenescence) and the …