The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Gene therapy has long sought to treat disease by delivering therapeutic genes to diseased
cells. However, its widespread clinical use has faltered in the face of several challenges …

Introduction: The delivery of nucleic acid therapeutics through non-viral carriers face multiple
biological barriers that reduce their therapeutic efficiency. Despite great progress, there …

Polymeric vehicles are versatile tools for therapeutic gene delivery. Many polymers—when
assembled with nucleic acids into vehicles—can protect the cargo from degradation and …

The ability to safely and precisely deliver genetic materials to target sites in complex
biological environments is vital to the success of gene therapy. Numerous viral and nonviral …

As an option for genetic disease treatment and an alternative for traditional cancer
chemotherapy, gene therapy achieves significant attention. Nucleic acid delivery, however …

Polymeric materials have been extensively developed as a delivery vehicle for nucleic acids
over the past two decades. Many previous studies have demonstrated that synthetic delivery …

In the post genomic era, massive genetic information of the human being accelerates the
identification of target genes for treating various diseases. A wide range of nucleic acid …

Intracellular nucleic acid delivery has the potential to treat many genetically-based diseases,
however, gene delivery safety and efficacy remains a challenging obstacle. One promising …

A number of human diseases stem from defective genes. One approach to treating such
diseases is to replace, or override, the defective genes with normal genes, an approach …