Background and Purpose—The spontaneously hypertensive rat (SHR) is vulnerable to brain
ischemia and stress and exhibits a chronically stimulated brain angiotensin II system …

Background and Purpose—Blockade of angiotensin II AT1 receptors in cerebral
microvessels protects against brain ischemia and inflammation. In this study, we tried to …

Objectives To elucidate the mechanisms of activation of polymorphonuclear neutrophils
(PMNs) and their adhesion to endothelial cells in hypertensive cerebral injury, and to …

Endothelial dysfunction and inflammation enhance vulnerability to hypertensive brain
damage. To explore the participation of Angiotensin II (Ang II) in the mechanism of …

Inhibition of angiotensin II AT1 receptors protects against stroke, reducing the cerebral blood
flow decrease in the periphery of the ischemic lesion. To clarify the mechanism …

Background Angiotensin II type 1 (AT1) receptor blockers decrease ischemia by
mechanisms dependent on and independent of arterial blood pressure in hypertensive rats …

Background and Purpose—Angiotensin-converting enzyme inhibitors have been shown to
protect against stroke in hypertensive rats and to improve neurological outcome after …

Angiotensin II exerts its central nervous system effects primarily via its receptors AT1 and
AT2, and it participates in the pathogenesis of ischemia via AT1. The selective AT1 receptor …

Background and Purpose—Angiotensin II, through stimulation of AT1 receptors, not only
controls blood pressure but also modulates cerebrovascular flow. We sought to determine …

Background and Purpose—The aim of the study was to examine how focal cerebral
ischemia affects the expression and function of vascular angiotensin II receptors. Materials …