Synthesis and in vitro antimalarial activity of a series of bisquinoline and bispyrrolo [1, 2a] quinoxaline compounds

L Van Heerden, TT Cloete, JW Breytenbach… - European journal of …, 2012 - Elsevier
Series of bisquinolines 4–15 and bispyrrolo [1, 2a] quinoxalines 16–20 containing various
polyamine linkers were synthesized. The aqueous solubility and distribution coefficient were …

Design, synthesis and in vitro antiplasmodial activity of some bisquinolines against chloroquine‐resistant strain

S Kondaparla, P Agarwal, K Srivastava… - Chemical Biology & …, 2017 - Wiley Online Library
A series of novel bisquinoline compounds comprising N1‐(7‐chloroquinolin‐4‐yl) ethane‐1,
2‐diamine and 7‐chloro‐N‐(2‐(piperazin‐1‐yl) ethyl) quinolin‐4‐amine connected with 7 …

Emergence of pyrido quinoxalines as new family of antimalarial agents

AC Shekhar, PS Rao, B Narsaiah, AD Allanki… - European journal of …, 2014 - Elsevier
A series of novel N-alkyl dihydro pyrido quinoxaline derivatives were synthesized using
Gould–Jacobs reaction and evaluated their antimalarial activity in vitro against chloroquine …

Synthesis and in vitro evaluation of 4-trichloromethylpyrrolo [1, 2-a] quinoxalines as new antiplasmodial agents

N Primas, P Suzanne, P Verhaeghe, S Hutter… - European Journal of …, 2014 - Elsevier
Thanks to a preliminary in vitro screening of several CCl 3-substituted-nitrogen containing
heterocycles belonging to our chemical library, the 2-trichloromethylquinoxaline scaffold …

1,2-Substituted 4-(1H)-Quinolones: Synthesis, Antimalarial and Antitrypanosomal Activities in Vitro

A Wube, A Hüfner, W Seebacher, M Kaiser, R Brun… - Molecules, 2014 - mdpi.com
A diverse array of 4-(1 H)-quinolone derivatives bearing substituents at positions 1 and 2
were synthesized and evaluated for antiprotozoal activities against Plasmodium falciparum …

Original quinazoline derivatives displaying antiplasmodial properties

Y Kabri, N Azas, A Dumetre, S Hutter, M Laget… - European journal of …, 2010 - Elsevier
The multistep synthesis of new quinazoline-derived molecules and their in vitro
antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is …

Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives

J Guillon, A Cohen, NM Gueddouda… - Journal of enzyme …, 2017 - Taylor & Francis
Novel series of bis-and tris-pyrrolo [1, 2-a] quinoxaline derivatives 1 were synthesized and
tested for in vitro activity upon the intraerythrocytic stage of W2 and 3D7 Plasmodium …

Synthesis and structure–activity relationship of 3-phenylquinoxaline 1, 4-di-N-oxide derivatives as antimalarial agents

E Vicente, LM Lima, E Bongard, S Charnaud… - European journal of …, 2008 - Elsevier
As a continuation of our research and with the aim of obtaining new antimalarial agents, new
series of 3-phenylquinoxaline 1, 4-di-N-oxide derivatives have been synthesized following …

New quinoline-5, 8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain

H Hussain, S Specht, SR Sarite, A Hoerauf… - European journal of …, 2012 - Elsevier
We report on the design, synthesis, and in vitro evaluation of new quinoline-5, 8-dione and
hydroxynaphthoquinone derivatives. The synthesized compounds were evaluated for in vitro …

New ferrocenic pyrrolo [1, 2-a] quinoxaline derivatives: synthesis, and in vitro antimalarial activity

J Guillon, S Moreau, E Mouray, V Sinou, I Forfar… - Bioorganic & medicinal …, 2008 - Elsevier
Following our search for antimalarial compounds, novel series of ferrocenic pyrrolo [1, 2-a]
quinoxaline derivatives 1–2 were synthesized from various substituted nitroanilines and …