Roles of peroxisome proliferator-activated receptor gamma on brain and peripheral inflammation

S Villapol - Cellular and molecular neurobiology, 2018 - Springer
Peroxisome proliferator-activated receptor gamma (PPARγ) has been implicated in the
pathology of numerous diseases involving diabetes, stroke, cancer, or obesity. It is …

Peroxisome proliferator-activated receptor-gamma (PPAR-ɣ): molecular effects and its importance as a novel therapeutic target for cerebral ischemic injury

A Mannan, N Garg, TG Singh, HK Kang - Neurochemical Research, 2021 - Springer
Cerebral ischemic injury is a leading cause of death and long-term disability throughout the
world. Peroxisome proliferator-activated receptor gamma (PPAR-ɣ) is a ligand-activated …

PPAR-γ: therapeutic target for ischemic stroke

J Culman, Y Zhao, P Gohlke, T Herdegen - Trends in pharmacological …, 2007 - cell.com
The peroxisome proliferator activated receptors (PPARs), which belong to the nuclear
receptor superfamily, are key regulators of glucose and fat metabolism. The PPAR-γ isoform …

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

W Cai, T Yang, H Liu, L Han, K Zhang, X Hu… - Progress in …, 2018 - Elsevier
Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

Minutes of PPAR-γ agonism and neuroprotection

BRP Kumar, AP Kumar, JA Jose, P Prabitha… - Neurochemistry …, 2020 - Elsevier
Peroxisome proliferator-activated receptor gamma (PPAR-γ) is one of the ligand-activated
transcription factors which regulates a number of central events and considered as a …

[HTML][HTML] The protective effects of peroxisome proliferator-activated receptor gamma in cerebral ischemia-reperfusion injury

Y Ding, J Kang, S Liu, Y Xu, B Shao - Frontiers in Neurology, 2020 - frontiersin.org
Cerebral ischemia-reperfusion injury (CI/RI) is a complex pathological process that often
occurs secondary to trauma, surgery, and shock. Peroxisome proliferator activated receptor …

Neuronal PPARγ deficiency increases susceptibility to brain damage after cerebral ischemia

X Zhao, R Strong, J Zhang, G Sun, JZ Tsien… - Journal of …, 2009 - Soc Neuroscience
Peroxisome proliferator-activated receptor gamma (PPARγ) plays a role in regulating a
myriad of biological processes in virtually all brain cell types, including neurons. We and …

PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases

R Bordet, T Ouk, O Petrault, P Gele… - Biochemical Society …, 2006 - portlandpress.com
PPARs (peroxisome-proliferator-activated receptors) are ligand-activated transcriptional
factor receptors belonging to the so-called nuclear receptor family. The three isoforms of …

PPARs in the central nervous system: roles in neurodegeneration and neuroinflammation

JM Zolezzi, MJ Santos, S Bastías‐Candia… - Biological …, 2017 - Wiley Online Library
Over 25 years have passed since peroxisome proliferators‐activated receptors (PPARs),
were first described. Like other members of the nuclear receptors superfamily, PPARs have …

PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury

M Collino, NSA Patel… - Therapeutic Advances in …, 2008 - journals.sagepub.com
Stroke is a leading cause of death and long-term disability in industrialized countries.
Despite advances in understanding its pathophysiology, little progress has been made in …