Selective autophagy is the lysosomal degradation of specific intracellular components
sequestered into autophagosomes, late endosomes, or lysosomes through the activity of …

Autophagy has burgeoned rapidly as a field of study because of its evolutionary
conservation, the diversity of intracellular cargoes degraded and recycled by this machinery …

Macroautophagy was initially considered to be a nonselective process for bulk breakdown of
cytosolic material. However, recent evidence points toward a selective mode of autophagy …

The clearance of surplus, broken, or dangerous components is key for maintaining cellular
homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular …

Summary (Macro) autophagy is a fundamental degradation process for macromolecules and
organelles of vital importance for cell and tissue homeostasis. Autophagy research has …

Selective autophagy is critical for regulating cellular homeostasis by mediating lysosomal
turnover of a wide variety of substrates including proteins, aggregates, organelles, and …

Neurons are electrically excitable, postmitotic cells that perform sensory, relaying, and motor
functions. Because of their unique morphological and functional specialization, cells of this …

Selective autophagy relies on soluble or membrane-bound cargo receptors that recognize
cargo and bring about autophagosome formation at the cargo. The cargo-bound receptors …

Selective autophagy eliminates protein aggregates, damaged organelles, and other targets
that otherwise accumulate and cause disease. Autophagy receptors mediate selectivity by …

Autophagy has long been thought to be an essential but unselective bulk degradation
pathway. However, increasing evidence suggests selective autophagosomal turnover of a …