Leveraging machine learning for gaining neurobiological and nosological insights in psychiatric research

J Chen, KR Patil, BTT Yeo, SB Eickhoff - Biological psychiatry, 2023 - Elsevier
Much attention is currently devoted to developing diagnostic classifiers for mental disorders.
Complementing these efforts, we highlight the potential of machine learning to gain …

Machine learning for psychiatry: getting doctors at the black box?

DM Hedderich, SB Eickhoff - Molecular psychiatry, 2021 - nature.com
Recent developments in the field of machine learning have spurred high hopes for
diagnostic support for psychiatric patients based on brain MRI. But while technical advances …

Current approaches in computational psychiatry for the data-driven identification of brain-based subtypes

LR Brucar, E Feczko, DA Fair, A Zilverstand - Biological psychiatry, 2023 - Elsevier
The ability of our current psychiatric nosology to accurately delineate clinical populations
and inform effective treatment plans has reached a critical point with only moderately …

Machine learning with neuroimaging: evaluating its applications in psychiatry

AN Nielsen, DM Barch, SE Petersen… - Biological Psychiatry …, 2020 - Elsevier
Psychiatric disorders are complex, involving heterogeneous symptomatology and
neurobiology that rarely involves the disruption of single, isolated brain structures. In an …

Machine learning for precision psychiatry

D Bzdok, A Meyer-Lindenberg - arXiv preprint arXiv:1705.10553, 2017 - arxiv.org
The nature of mental illness remains a conundrum. Traditional disease categories are
increasingly suspected to mis-represent the causes underlying mental disturbance. Yet …

Machine learning for precision psychiatry: opportunities and challenges

D Bzdok, A Meyer-Lindenberg - Biological Psychiatry: Cognitive …, 2018 - Elsevier
The nature of mental illness remains a conundrum. Traditional disease categories are
increasingly suspected to misrepresent the causes underlying mental disturbance. Yet …

Anatomical brain images alone can accurately diagnose chronic neuropsychiatric illnesses

R Bansal, LH Staib, AF Laine, X Hao, D Xu, J Liu… - PloS one, 2012 - journals.plos.org
Objective Diagnoses using imaging-based measures alone offer the hope of improving the
accuracy of clinical diagnosis, thereby reducing the costs associated with incorrect …

[HTML][HTML] Beyond lumping and splitting: a review of computational approaches for stratifying psychiatric disorders

AF Marquand, T Wolfers, M Mennes, J Buitelaar… - Biological psychiatry …, 2016 - Elsevier
Heterogeneity is a key feature of all psychiatric disorders that manifests on many levels,
including symptoms, disease course, and biological underpinnings. These form a …

The heterogeneity problem: approaches to identify psychiatric subtypes

E Feczko, O Miranda-Dominguez, M Marr… - Trends in cognitive …, 2019 - cell.com
The imprecise nature of psychiatric nosology restricts progress towards characterizing and
treating mental health disorders. One issue is the 'heterogeneity problem': different causal …

A systematic evaluation of machine learning-based biomarkers for major depressive disorder across modalities

NR Winter, J Blanke, R Leenings, J Ernsting, L Fisch… - medRxiv, 2023 - medrxiv.org
Background Biological psychiatry aims to understand mental disorders in terms of altered
neurobiological pathways. However, for one of the most prevalent and disabling mental …