Epigenetic regulation of aging: implications for interventions of aging and diseases

K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Epigenetics of aging and aging-related disease

A Brunet, SL Berger - Journals of Gerontology Series A …, 2014 - academic.oup.com
Aging is associated with a wide range of human disorders, including cancer, diabetes,
cardiovascular, and neurodegenerative diseases. Long thought to be an inexorable road …

The ageing epigenome and its rejuvenation

W Zhang, J Qu, GH Liu, JCI Belmonte - Nature reviews Molecular cell …, 2020 - nature.com
Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …

Epigenetic mechanisms of aging and aging-associated diseases

A la Torre, F Lo Vecchio, A Greco - Cells, 2023 - mdpi.com
Aging is an inevitable outcome of life, characterized by a progressive decline in tissue and
organ function. At a molecular level, it is marked by the gradual alterations of biomolecules …

[HTML][HTML] Epigenetic mechanisms of longevity and aging

P Sen, PP Shah, R Nativio, SL Berger - Cell, 2016 - cell.com
Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Hot topics in epigenetic mechanisms of aging: 2011

M Berdasco, M Esteller - Aging cell, 2012 - Wiley Online Library
Aging is a complex process that results in compromised biological functions of the organism
and increased susceptibility to disease and death. Although the molecular basis of aging is …

How to slow down the ticking clock: age-associated epigenetic alterations and related interventions to extend life span

AM Galow, S Peleg - Cells, 2022 - mdpi.com
Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

Epigenetic control of aging

U Munoz-Najar, JM Sedivy - Antioxidants & redox signaling, 2011 - liebertpub.com
Organismal aging and longevity are influenced by many complex interacting factors.
Epigenetics has recently emerged as another possible determinant of aging. Here, we …

[PDF][PDF] The aging epigenome

LN Booth, A Brunet - Molecular cell, 2016 - cell.com
During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

[HTML][HTML] Epigenetic regulation of aging

S Rodríguez-Rodero… - Discovery …, 2010 - discoverymedicine.com
Aging is one of the most challenging and unresolved problems in biology owing to its highly
complex nature. Public interest in aging has increased not only because all of us can expect …