Fluorouracil (5FU) exposure can lead to both G1/S arrest and apoptosis induction which are
dependent of P53 induction. The human papilloma virus oncoproteins (HPV), E6 and E7 …

OBJECTIVE: To investigate the cytotoxic effect of 5-fluorouracil (5Fu) on HPV16-associated
laryngeal cancer cells. DESIGN AND METHODS: Cytotoxicity assay and TUNEL assay were …

The E6 gene of tumor‐associated types of human papillomaviruses codes for a functional
antagonist of p53. Overexpression of E6 from heterologous promoters can block p53 …

An important characteristic of cancers associated with high-risk human papillomaviruses
(HR-HPV) is the inability of p53 to activate apoptosis due to the effect of the oncoprotein E6 …

PURPOSE 5-Fluorouracil (5-FU) is a commonly used chemotherapeutic agent in the
treatment of laryngeal squamous cell carcinoma. 5-FU can induce cell cycle arrest or …

The p53 tumor suppressor pathway is disrupted by human papillomavirus (HPV) in most
cervical cancer cells. The E6 proteins, which could mediate p53 degradation, are related to …

ABSTRACT Transcription Factor E2F‐1 plays a critical role in cell cycle regulation and other
biological processes in cells. However whether or not it is involved in the multi‐drug …

Deletion of p53, most common genetic alteration, is observed in human tumors and reported
to lead to improve in cell radioresistance. Heavy‐ion irradiation (IR) could induce p53 …

By using a mouse NIH3T3 derivate designed 7-4 harboring the inducible Ha-ras oncogene,
we demonstrated the close relationship between Ha-ras expression level and sensitization …

To evaluate the effect of HPV16 E6/E7 on drug sensitivity, primary human OSE cells were
infected with HPV16 E6/E7 expressing retrovirus and then exposed to chemotherapeutic …