SARS-CoV-2 infection dysregulates host iron (Fe)-redox homeostasis (Fe-RH): role of Fe-redox regulators, ferroptosis inhibitors, anticoagulants, and iron-chelators in …

SAG Naidu, RA Clemens, AS Naidu - Journal of dietary …, 2023 - Taylor & Francis
Severe imbalance in iron metabolism among SARS-CoV-2 infected patients is prominent in
every symptomatic (mild, moderate to severe) clinical phase of COVID-19. Phase-I–Hypoxia …

[HTML][HTML] The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators

HM Habib, S Ibrahim, A Zaim, WH Ibrahim - Biomedicine & …, 2021 - Elsevier
Iron overload is increasingly implicated as a contributor to the pathogenesis of COVID-19.
Indeed, several of the manifestations of COVID-19, such as inflammation, hypercoagulation …

Iron and iron-related proteins in COVID-19

E Suriawinata, KJ Mehta - Clinical and experimental medicine, 2023 - Springer
COVID-19 can cause detrimental effects on health. Vaccines have helped in reducing
disease severity and transmission but their long-term effects on health and effectiveness …

Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients' performance: a prospective …

T Sonnweber, A Boehm, S Sahanic, A Pizzini… - Respiratory …, 2020 - Springer
Background Severe coronavirus disease 2019 (COVID-19) is frequently associated with
hyperinflammation and hyperferritinemia. The latter is related to increased mortality in …

Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?

M Edeas, J Saleh, C Peyssonnaux - International Journal of Infectious …, 2020 - Elsevier
Abstract The coronavirus 2 (SARS-CoV-2) pandemic is viciously spreading through the
continents with rapidly increasing mortality rates. Current management of COVID-19 is …

COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy

C Perricone, E Bartoloni, R Bursi, G Cafaro… - Immunologic …, 2020 - Springer
SARS-CoV-2 infection is characterized by a protean clinical picture that can range from
asymptomatic patients to life-threatening conditions. Severe COVID-19 patients often display …

Commentary: Could iron chelators prove to be useful as an adjunct to COVID-19 Treatment Regimens?

M Dalamaga, I Karampela, CS Mantzoros - Metabolism, 2020 - Elsevier
The pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) poses a significant threat to global health. Currently, no specific prophylactic …

Hyperferritinemia, low circulating iron and elevated hepcidin may negatively impact outcome in COVID-19 patients: a pilot study

R Szabo, C Petrisor, C Bodolea, R Simon, I Maries… - Antioxidants, 2022 - mdpi.com
Inflammation in COVID-19 produces intracellular iron overload with low circulating iron
available for metabolic processes. The accumulated intracellular iron generates reactive …

Infection-iron interaction during COVID-19 pandemic: Time to re-design iron supplementation programs

LF Augustine, V Mullapudi, S Subramanian… - Medical …, 2020 - ncbi.nlm.nih.gov
Several countries with high prevalence of nutritional anaemia implement population based
iron supplementation programs for anaemia reduction. With large population sections in …

Cardiac iron overload promotes cardiac injury in patients with severe COVID-19

MJ Baier, S Wagner, J Hupf, K Evert, M Evert… - Infection, 2022 - Springer
During the current SARS-CoV-2-pandemic, involvement of multiple organs in addition to the
respiratory tract has been observed. Cardiac manifestations, such as acute heart failure …