Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Podocytes of the renal glomerulus are unique cells with a complex cellular organization
consisting of a cell body, major processes and foot processes. Podocyte foot processes form …

Proteinuria encompasses diverse causes including both genetic diseases and acquired
forms such as diabetic and hypertensive nephropathy. The basis of proteinuria is a …

Podocytes form an epithelial layer on the outer aspect of the basement membrane of
glomerular capillaries. The interdigitating pattern of podocyte foot processes (PFPs) …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Almost all mammalian cell types have morphologies that are uniquely tailored to their
physiological functions. This immense variation in cell shape depends on an underlying …

Glomerular injury often incites a progression to chronic kidney disease, which affects
millions of patients worldwide. Despite our current understanding of this disease's …

Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their
function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte …

The visceral glomerular epithelial cell, also known as the podocyte, plays an important role
in the maintenance of renal glomerular function. This cell type is highly specialized and its …

Glomerular podocytes are highly polarized cells characterized by dynamic actin-based foot
processes (FPs). Neighboring FPs form specialized junctions, slit diaphragms (SDs), which …