Female androgen excess and male androgen deficiency manifest with an overlapping
adverse metabolic phenotype, including abdominal obesity, insulin resistance, type 2 …

Objective In men, androgen deprivation contributes to the development of metabolic
syndrome and type 2 diabetes (T2D). In women, androgen excess predisposes to insulin …

Androgen excess in women and androgen deficiency in men facilitate abdominal adiposity
and related metabolic disorders. Moreover, obesity-associated gonadal dysfunction consists …

Androgens play an important role in regulation of body fat distribution in humans. They exert
direct effects on adipocyte differentiation in a depot-specific manner, via the androgen …

OBJECTIVE: This review discusses androgen status in male and female obesity, according
to their specific phenotype, and the main mechanisms responsible. DESIGN: Published data …

Adipose tissue is an important target of androgen action in humans. Androgens exert
important effects on adipose tissue biology, including fat mass expansion and distribution …

The sexual dimorphism in human body fat distribution suggests a causal role for sex
hormones. This is of particular importance when considering the role of excess visceral …

An important sex difference in body fat distribution is generally observed. Men are usually
characterized by the android type of obesity, with accumulation of fat in the abdominal …

Published data on the effects of androgen deficiency and testosterone administration on
body composition in men and women are reviewed. In experimental paradigms, androgen …

Androgens modulate adipocyte function and affect the size of adipose tissue compartments
in humans. Aldo-keto reductase 1C (AKR1C) enzymes, especially AKR1C2 and AKR1C3 …