De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

G Kirov, AJ Pocklington, P Holmans, D Ivanov… - Molecular …, 2012 - nature.com
A small number of rare, recurrent genomic copy number variants (CNVs) are known to
substantially increase susceptibility to schizophrenia. As a consequence of the low fecundity …

Copy number variations in schizophrenia: critical review and new perspectives on concepts of genetics and disease

AS Bassett, SW Scherer… - American Journal of …, 2010 - Am Psychiatric Assoc
Objective Structural variations of DNA, such as copy number variations (CNVs), are
recognized to contribute both to normal genomic variability and to risk for human diseases …

The role of DNA copy number variation in schizophrenia

GWC Tam, R Redon, NP Carter, SGN Grant - Biological psychiatry, 2009 - Elsevier
Schizophrenia is a major psychiatric disease with strong evidence of genetic risk factors.
Recent studies based on genome-wide study of copy number variations (CNVs) have …

CNV analysis in a large schizophrenia sample implicates deletions at 16p12.1 and SLC1A1 and duplications at 1p36.33 and CGNL1

E Rees, JTR Walters, KD Chambert… - Human molecular …, 2014 - academic.oup.com
Large and rare copy number variants (CNVs) at several loci have been shown to increase
risk for schizophrenia. Aiming to discover novel susceptibility CNV loci, we analyzed 6882 …

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

CR Marshall, DP Howrigan, D Merico… - Nature …, 2017 - nature.com
Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk …

De novo rates and selection of schizophrenia-associated copy number variants

E Rees, V Moskvina, MJ Owen, MC O'Donovan… - Biological …, 2011 - Elsevier
BACKGROUND: At least 10 large and rare recurrent DNA copy number variants (CNVs)
have been identified as risk factors for schizophrenia and other neurodevelopmental …

Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia

D Grozeva, G Kirov, D Ivanov, IR Jones… - Archives of general …, 2010 - jamanetwork.com
Context Recent studies suggest that copy number variation in the human genome is
extensive and may play an important role in susceptibility to disease, including …

Strong synaptic transmission impact by copy number variations in schizophrenia

JT Glessner, MP Reilly, CE Kim… - Proceedings of the …, 2010 - National Acad Sciences
Schizophrenia is a psychiatric disorder with onset in late adolescence and unclear etiology
characterized by both positive and negative symptoms, as well as cognitive deficits. To …

High rate of disease-related copy number variations in childhood onset schizophrenia

K Ahn, N Gotay, TM Andersen, AA Anvari… - Molecular …, 2014 - nature.com
Copy number variants (CNVs) are risk factors in neurodevelopmental disorders, including
autism, epilepsy, intellectual disability (ID) and schizophrenia. Childhood onset …

New copy number variations in schizophrenia

C Magri, E Sacchetti, M Traversa, P Valsecchi… - PloS one, 2010 - journals.plos.org
Genome-wide screenings for copy number variations (CNVs) in patients with schizophrenia
have demonstrated the presence of several CNVs that increase the risk of developing the …