Genetics of 35 blood and urine biomarkers in the UK Biobank
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
[HTML][HTML] Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study
Background The role of urate in cardiovascular diseases (CVDs) has been extensively
investigated in observational studies; however, the extent of any causal effect remains …
investigated in observational studies; however, the extent of any causal effect remains …
[HTML][HTML] The UK Biobank resource with deep phenotyping and genomic data
C Bycroft, C Freeman, D Petkova, G Band, LT Elliott… - Nature, 2018 - nature.com
The UK Biobank project is a prospective cohort study with deep genetic and phenotypic data
collected on approximately 500,000 individuals from across the United Kingdom, aged …
collected on approximately 500,000 individuals from across the United Kingdom, aged …
A cross-population atlas of genetic associations for 220 human phenotypes
Current genome-wide association studies do not yet capture sufficient diversity in
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
[HTML][HTML] Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations
Serum biomarker levels are associated with the risk of complex diseases. Here, we aimed to
gain insights into the genetic architecture of biomarker traits which can reflect health status …
gain insights into the genetic architecture of biomarker traits which can reflect health status …
Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies
Improved understanding of genetic regulation of the proteome can facilitate identification of
the causal mechanisms for complex traits. We analyzed data on 4,657 plasma proteins from …
the causal mechanisms for complex traits. We analyzed data on 4,657 plasma proteins from …
[PDF][PDF] Genomewide association studies--illuminating biologic pathways
JN Hirschhorn - New England journal of medicine, 2009 - enigma.ini.usc.edu
Human geneticists seek to understand the inherited basis of human biology and disease,
aiming either to gain insights that could eventually improve treatment or to produce useful …
aiming either to gain insights that could eventually improve treatment or to produce useful …
[HTML][HTML] Molecular insights into genome-wide association studies of chronic kidney disease-defining traits
Genome-wide association studies (GWAS) have identified> 100 loci of chronic kidney
disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations …
disease-defining traits (CKD-dt). Molecular mechanisms underlying these associations …
[HTML][HTML] Large-scale plasma proteomics comparisons through genetics and disease associations
GH Eldjarn, E Ferkingstad, SH Lund, H Helgason… - Nature, 2023 - nature.com
High-throughput proteomics platforms measuring thousands of proteins in plasma combined
with genomic and phenotypic information have the power to bridge the gap between the …
with genomic and phenotypic information have the power to bridge the gap between the …
[HTML][HTML] The path from genome-based research to population health: development of an international public health genomics network
W Burke, MJ Khoury, A Stewart, RL Zimmern - Genetics in Medicine, 2006 - nature.com
The health benefits of the Human Genome Project have been widely anticipated. Experts
predict a new era of individualized disease prevention based on testing for genetic …
predict a new era of individualized disease prevention based on testing for genetic …