[HTML][HTML] Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

[HTML][HTML] Aging and age‐related diseases: from mechanisms to therapeutic strategies

Z Li, Z Zhang, Y Ren, Y Wang, J Fang, H Yue, S Ma… - Biogerontology, 2021 - Springer
Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

[HTML][HTML] The hallmarks of aging

C López-Otín, MA Blasco, L Partridge, M Serrano… - Cell, 2013 - cell.com
Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …

Molecular inflammation: underpinnings of aging and age-related diseases

HY Chung, M Cesari, S Anton, E Marzetti… - Ageing research …, 2009 - Elsevier
Recent scientific studies have advanced the notion of chronic inflammation as a major risk
factor underlying aging and age-related diseases. In this review, low-grade, unresolved …

[HTML][HTML] Key signaling pathways in aging and potential interventions for healthy aging

M Yu, H Zhang, B Wang, Y Zhang, X Zheng, B Shao… - Cells, 2021 - mdpi.com
Aging is a fundamental biological process accompanied by a general decline in tissue
function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive …

Aging: molecular pathways and implications on the cardiovascular system

AJPO Almeida, TP Ribeiro… - Oxidative medicine and …, 2017 - Wiley Online Library
The world's population over 60 years is growing rapidly, reaching 22% of the global
population in the next decades. Despite the increase in global longevity, individual …

[HTML][HTML] New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

T Schmauck-Medina, A Molière, S Lautrup… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss
of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion …

[HTML][HTML] Aging Process and Related Diseases

F Taheri, E Rahmani, SS Fard, M Rezaei, A Ayati… - Kindle, 2023 - preferpub.org
The aging process is a complex biological phenomenon that results in the gradual decline of
physiological function and an increased risk of age-related diseases. While aging is a …

[HTML][HTML] Genomic Instabilities, Cellular Senescence, and Aging: In Vitro, In Vivo and Aging-Like Human Syndromes

G Lidzbarsky, D Gutman, HA Shekhidem… - Frontiers in …, 2018 - frontiersin.org
As average life span and elderly people prevalence in the western world population is
gradually increasing, the incidence of age-related diseases such as cancer, heart diseases …

Signaling networks determining life span

CE Riera, C Merkwirth… - Annual review of …, 2016 - annualreviews.org
The health of an organism is orchestrated by a multitude of molecular and biochemical
networks responsible for ensuring homeostasis within cells and tissues. However, upon …