Genetic differences associated with dopamine and serotonin release mediate fear-induced bradycardia in the human brain

S Battaglia, C Nazzi, JF Thayer - Translational psychiatry, 2024 - nature.com
Fear-induced bradycardia, a transient heartbeat deceleration following exposure to threat, is
a physiological index observable in humans, especially in fear conditioning experiments …

[HTML][HTML] Fear-induced bradycardia in mental disorders: Foundations, current advances, future perspectives

S Battaglia, C Nazzi, JF Thayer - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
Fear-induced bradycardia, a transient heart rate deceleration related to a threatening event,
is a powerful technique used to assess fear conditioning in humans. During the last century …

Neuropsychobiology of fear-induced bradycardia in humans: progress and pitfalls

S Battaglia, C Nazzi, TB Lonsdorf, JF Thayer - Molecular Psychiatry, 2024 - nature.com
In the last century, the paradigm of fear conditioning has greatly evolved in a variety of
scientific fields. The techniques, protocols, and analysis methods now most used have …

Characterizing cardiac autonomic dynamics of fear learning in humans

S Battaglia, S Orsolini, S Borgomaneri… - …, 2022 - Wiley Online Library
Understanding transient dynamics of the autonomic nervous system during fear learning
remains a critical step to translate basic research into treatment of fear‐related disorders. In …

Resting heart rate variability is associated with inhibition of conditioned fear

J Wendt, J Neubert, J Koenig, JF Thayer… - …, 2015 - Wiley Online Library
Startle blink as well as skin conductance responses (SCR) are widely used indices of
learning processes associated with fear conditioning and extinction. During safety learning …

Individual differences in fear-potentiated startle as a function of resting heart rate variability: implications for panic disorder

CA Melzig, AI Weike, AO Hamm, JF Thayer - International Journal of …, 2009 - Elsevier
BACKGROUND: Anticipatory anxiety, which can be indexed by the startle potentiation to a
threat of shock, has been implicated in the development of panic disorder. Large individual …

Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes

MC Camp, KP MacPherson, L Lederle… - …, 2012 - nature.com
Mood and anxiety disorders develop in some but not all individuals following exposure to
stress and psychological trauma. However, the factors underlying individual differences in …

Associations between serotonin-related gene polymorphisms and panic disorder

E Maron, A Lang, G Tasa, L Liivlaid… - International Journal …, 2005 - academic.oup.com
Studies suggest that vulnerability to panic attacks and panic disorder (PD) may be related to
a deficient serotonin (5-HT) neurotransmission. In the present case-control study we …

Serotonin function in panic disorder: important, but why?

E Maron, J Shlik - Neuropsychopharmacology, 2006 - nature.com
The essential role of serotonin (5-hydroxytryptamine (5-HT)) system in the neurobiology and
pharmacotherapy of panic disorder (PD) continues to be a topic of intensive interdisciplinary …

Serotonin transporter gene variation impacts innate fear processing: acoustic startle response and emotional startle

B Brocke, D Armbruster, J Muller, T Hensch… - Molecular …, 2006 - nature.com
Anxiety-related behaviors are closely linked to neural circuits relaying fear-specific
information to the amygdala. Many of these circuits, like those underlying processing of …