Klotho, aging, and the failing kidney

S Buchanan, E Combet, P Stenvinkel… - Frontiers in …, 2020 - frontiersin.org
Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

[HTML][HTML] Klotho: an antiaging protein involved in mineral and vitamin D metabolism

PU Torres, D Prie, V Molina-Bletry, L Beck, C Silve… - Kidney international, 2007 - Elsevier
Klotho gene mutation leads to a syndrome strangely resembling chronic kidney disease
patients undergoing dialysis with multiple accelerated age-related disorders, including …

Secreted klotho and chronic kidney disease

MC Hu, M Kuro-o, OW Moe - Endocrine FGFs and Klothos, 2012 - Springer
Soluble Klotho (sKl) in the circulation can be generated directly by alterative splicing of the
Klotho transcript or the extracellular domain of membrane Klotho can be released from …

The kidney is the principal organ mediating klotho effects

K Lindberg, R Amin, OW Moe, MC Hu… - Journal of the …, 2014 - journals.lww.com
Klotho was discovered as an antiaging gene, and α-Klotho (Klotho) is expressed in multiple
tissues with a broad set of biologic functions. Membrane-bound Klotho binds fibroblast …

Role of Klotho in aging, phosphate metabolism, and CKD

GB John, CY Cheng, M Kuro-o - American journal of kidney diseases, 2011 - Elsevier
The klotho gene (KL) was identified first as a putative aging-suppressor gene that extended
life span when overexpressed and accelerated aging-like phenotypes when disrupted in …

[HTML][HTML] Biological role of anti-aging protein Klotho

JH Kim, KH Hwang, KS Park, ID Kong… - Journal of lifestyle …, 2015 - ncbi.nlm.nih.gov
Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of
Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein …

Klotho and chronic kidney disease

MC Hu, M Kuro-o, OW Moe - Phosphate and Vitamin D in Chronic …, 2013 - karger.com
Through alternative splicing, Klotho protein exists both as a secreted and a membrane form
whose extracellular domain could be shed from the cell surface by secretases and released …

[HTML][HTML] Upstream and downstream regulators of Klotho expression in chronic kidney disease

SS Li, M Sheng, ZY Sun, Y Liang, LX Yu, QF Liu - Metabolism, 2023 - Elsevier
Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …

Pathobiology of the klotho antiaging protein and therapeutic considerations

GJ Prud'homme, M Kurt, Q Wang - Frontiers in Aging, 2022 - frontiersin.org
The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Epigenetic and non-epigenetic regulation of Klotho in kidney disease

A Kale, H Sankrityayan, HJ Anders, AB Gaikwad - Life sciences, 2021 - Elsevier
Klotho is a novel renoprotective anti-aging protein available in membrane-bound or soluble
form. Klotho is expressed in brain, pancreas, and other solid organs but shows highest …