Cells manage to survive, thrive, and divide with high accuracy despite the constant threat of
DNA damage. Cells have evolved with several systems that efficiently repair spontaneous …

DNA damage of exposed tumour tissue leading to cell death is one of the detrimental effects
of ionising radiation that is exploited, with beneficial consequences, for radiotherapy. The …

Clustered DNA lesions, also called Multiply Damaged Sites, is the hallmark of ionizing
radiation. It is defined as the combination of two or more lesions, comprising strand breaks …

A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites,
defined as two or more lesions within one to two helical turns of DNA by passage of a single …

The accumulated evidence in the literature indicates that a cluster of two or more lesions
within one or two helical turns of the DNA is more challenging to repair than individual …

A clustered DNA lesion, also known as a multiply damaged site, is defined as≥ 2 damages
in the DNA within 1–2 helical turns. Only ionizing radiation and certain chemicals introduce …

After living cells are exposed to ionizing radiation, a variety of chemical modifications of DNA
are induced either directly by ionization of DNA or indirectly through interactions with water …

Clustered DNA damage induced by ionizing radiation is refractory to repair and may trigger
carcinogenic events for reasons that are not well understood. Here, we used an in situ …

Clustered DNA damage sites, in which two or more lesions are formed within a few helical
turns of the DNA after passage of a single radiation track, are signatures of DNA …

Abstract Hada, M. and Sutherland, BM Spectrum of Complex DNA Damages Depends on
the Incident Radiation. Radiat. Res. 165, 223–230 (2006). Ionizing radiation induces …