Antibodies serve as critical barriers to viral infection. Humoral immunity to a virus is achieved
through the dual role of antibodies in communicating the presence of invading pathogens in …

The antibody response plays a key role in protection against viral infections. While antiviral
antibodies may reduce the viral burden via several mechanisms, the ability to directly inhibit …

Antibodies are the principal immune effectors that mediate protection against reinfection
following viral infection or vaccination. Robust techniques for human mAb isolation have …

A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive
immune response. The widely held view has been that the great variability of viral …

Host responses to infectious challenges include initial events elicited directly by agent
structures distinct from host determinants, activation of innate immune system components …

New modes of humoral recognition have been identified by studies of antibodies that
neutralize human immunodeficiency virus type 1 and influenza A viruses. Understanding …

Highlights•Broadly neutralizing HIV-1 and influenza antibodies possess significant levels of
affinity maturation.•Choice of initial immunogens may be critical to select naïve B cells that …

Certain human pathogens avoid elimination by our immune system by rapidly mutating the
surface protein sites targeted by antibody responses, and consequently they tend to be …

The natural human antibody response is a rich source of highly specific, neutralizing and
self-tolerant therapeutic reagents. Recent advances have been made in isolating and …

Viruses as obligate intracellular parasites require their host to replicate them and to facilitate
their spread to others. In humans, viral infections are rarely lethal, even if they are highly …