Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets
Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-
specific epigenomic annotations and 3D genome information we generated and validated …
specific epigenomic annotations and 3D genome information we generated and validated …
[HTML][HTML] Kidney omics in hypertension: from statistical associations to biological mechanisms and clinical applications
M Tomaszewski, AP Morris, JMM Howson… - Kidney international, 2022 - Elsevier
Hypertension is a major cardiovascular disease risk factor and contributor to premature
death globally. Family-based investigations confirmed a significant heritable component of …
death globally. Family-based investigations confirmed a significant heritable component of …
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney
The kidney is an organ of key relevance to blood pressure (BP) regulation, hypertension and
antihypertensive treatment. However, genetically mediated renal mechanisms underlying …
antihypertensive treatment. However, genetically mediated renal mechanisms underlying …
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney
Elevated blood pressure is a major risk factor for cardiovascular disease and has a
substantial genetic contribution. Genetic variation influencing blood pressure has the …
substantial genetic contribution. Genetic variation influencing blood pressure has the …
Large-scale multi-omics studies provide new insights into blood pressure regulation
Recent genome-wide association studies uncovered part of blood pressure's heritability.
However, there is still a vast gap between genetics and biology that needs to be bridged …
However, there is still a vast gap between genetics and biology that needs to be bridged …
Transcriptome-and proteome-wide association studies nominate determinants of kidney function and damage
Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …
From GWAS to functional genomics-based precision medicine
DL Mattson, M Liang - Nature Reviews Nephrology, 2017 - nature.com
Several recent studies have provided insights into the genetic regulation of blood pressure.
A new study extends these findings by coupling genome-wide association study data with …
A new study extends these findings by coupling genome-wide association study data with …
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure
to identify genes, tissues, phenomes and medication contexts of blood pressure …
to identify genes, tissues, phenomes and medication contexts of blood pressure …
Genomics and precision medicine for clinicians and scientists in hypertension
Dominiczak et al Genomics and Precision Medicine e11 descent. 16 Similar to previous
studies, 66 SNP genetic risk scores were significantly associated with target organ damage …
studies, 66 SNP genetic risk scores were significantly associated with target organ damage …
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease
More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …
dysfunction is poorly understood. In the present study, we define the genetic association with …