Eukaryotic stress granules (SGs) are highly dynamic assemblies of untranslated mRNAs
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …

Until recently, the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy were
considered to be two independent systems that target proteins for degradation by …

Sequestration of protein aggregates in inclusion bodies and their subsequent degradation
prevents proteostasis imbalance, cytotoxicity, and proteinopathies. The underlying …

Stress granules (SGs) are ribonucleoprotein complexes induced by stress. They sequester
mRNAs and disassemble when the stress subsides, allowing translation restoration. In …

ABSTRACT TRIM37 gene mutations cause mulibrey (muscle-liver-brain-eye) nanism, a
severe growth disorder with prenatal onset. Although TRIM37 depletion normally induces …

Macroautophagy/autophagy is a multistep cellular process that sequesters cytoplasmic
components for lysosomal degradation. BECN1/Beclin1 is a central protein that assembles …

Cytoplasmic stress granules (SGs) are dynamic foci containing translationally arrested
mRNA and RNA-binding proteins (RBPs) that form in response to a variety of cellular …

Stress granules (SGs) are cytoplasmic assemblies of mRNPs stalled in translation initiation.
They are induced by various stress conditions, including exposure to the environmental …

Stress granules (SGs) assemble under stress-induced conditions that inhibit protein
synthesis, including phosphorylation of eIF2α, inhibition of the RNA helicase eIF4a proteins …

Stress granules (SGs) are cytoplasmic condensates containing untranslated mRNP
complexes. They are induced by various proteotoxic conditions such as heat, oxidative, and …