The management of extrapulmonary comorbidities and treatable traits; obesity, physical inactivity, anxiety, and depression, in adults with asthma

RF McLoughlin, VM McDonald - Frontiers in Allergy, 2021 - frontiersin.org
Asthma is a complex and heterogenous disease characterized by variability in disease
expression and severity. Multiple extrapulmonary comorbidities and treatable traits are …

Comorbid “treatable traits” in difficult asthma: current evidence and clinical evaluation

TR Tay, M Hew - Allergy, 2018 - Wiley Online Library
The care of patients with difficult‐to‐control asthma (“difficult asthma”) is challenging and
costly. Despite high‐intensity asthma treatment, these patients experience poor asthma …

Emerging comorbidities in adult asthma: risks, clinical associations, and mechanisms

H Kankaanranta, P Kauppi, LE Tuomisto… - Mediators of …, 2016 - Wiley Online Library
Asthma is a heterogeneous disease with many phenotypes, and age at disease onset is an
important factor in separating the phenotypes. Most studies with asthma have been …

The role of comorbidities in difficult-to-control asthma in adults and children

JM Gaffin, M Castro, LB Bacharier… - The Journal of Allergy and …, 2022 - Elsevier
Assessment of asthma comorbidities, conditions that adversely affect the pathobiology of
asthma or impair its response to therapies, is a fundamental step in the evaluation and …

Identification of asthma phenotypes based on extrapulmonary treatable traits

PD Freitas, RF Xavier, VM McDonald… - European …, 2021 - Eur Respiratory Soc
Asthma is a heterogeneous and complex disease, and a description of asthma phenotypes
based on extrapulmonary treatable traits has not been previously reported. The objective of …

Optimizing lifestyle interventions in adult patients with comorbid asthma and obesity

MM Kuder, SM Nyenhuis - Therapeutic Advances in …, 2020 - journals.sagepub.com
The prevalence of obesity and asthma are both increasing at alarming rates. The link
between obesity and asthma suggests that obesity contributes to both risk of new onset …

How to apply the personalized medicine in obesity-associated asthma?

A Tiotiu, M Labor, D Nedeva, S Novakova… - Expert Review of …, 2020 - Taylor & Francis
Introduction Obesity-associated asthma (OA) is frequently severe, with an increased rate of
hospitalizations, numerous comorbidities and low response to corticosteroids. Despite …

Asthma and three colinear comorbidities: obesity, OSA, and GERD

MD Althoff, A Ghincea, LG Wood, F Holguin… - The Journal of Allergy …, 2021 - Elsevier
Asthma is a complex disease with heterogeneous phenotypes and endotypes that are
incompletely understood. Obesity, obstructive sleep apnea, and gastroesophageal reflux …

Treatable Traits in Asthma: The importance of extra-pulmonary traits-GERD, CRSwNP, Atopic Dermatitis, and Depression/Anxiety

VM McDonald, Y Hamada, A Agusti… - The Journal of Allergy and …, 2024 - Elsevier
Treatable traits is a personalised medicine approach to the management of airway disease.
Assessing traits within the three domains of pulmonary, extra pulmonary and …

The added burden of comorbidity in patients with asthma

T Zhang, BC Carleton, RJ Prosser, AM Smith - Journal of Asthma, 2009 - Taylor & Francis
Objective. Compare the prevalence of comorbidities in adults with and without asthma in
Canada and investigate the association between comorbidities in patients with asthma and …