Targeting Akt/CREB/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach

SN Zarneshan, S Fakhri, H Khan - Pharmacological research, 2022 - Elsevier
Neurodegenerative diseases (NDDs) are leading causes of death and morbidity in the
elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation …

Ginsenosides and their CNS targets

K Radad, R Moldzio, WD Rausch - CNS neuroscience & …, 2011 - Wiley Online Library
Ginsenosides are a special group of triterpenoid saponins attributed to medical effects of
ginseng. Therefore, they have been research targets over the last three decades to explain …

Ginsenoside and its therapeutic potential for cognitive impairment

H Feng, M Xue, H Deng, S Cheng, Y Hu, C Zhou - Biomolecules, 2022 - mdpi.com
Cognitive impairment (CI) is one of the major clinical features of many neurodegenerative
diseases. It can be aging-related or even appear in non-central nerve system (CNS) …

Ginsenosides in central nervous system diseases: Pharmacological actions, mechanisms, and therapeutics

J Lu, X Wang, A Wu, Y Cao, X Dai… - Phytotherapy …, 2022 - Wiley Online Library
The nervous system is one of the most complex physiological systems, and central nervous
system diseases (CNSDs) are serious diseases that affect human health. Ginseng (Panax …

Neuroprotective mechanisms of ginsenoside Rb1 in central nervous system diseases

L Gong, J Yin, Y Zhang, R Huang, Y Lou… - Frontiers in …, 2022 - frontiersin.org
Panax ginseng and Panax notoginseng, two well-known herbs with enormous medical
value in Asian countries, have a long usage history in China for the therapy of some …

Ginsenoside Rd: A promising natural neuroprotective agent

YY Chen, QP Liu, P An, M Jia, X Luan, JY Tang… - Phytomedicine, 2022 - Elsevier
Background Neurological diseases seriously affect human health, which are arousing wider
attention, and it is a great challenge to discover neuroprotective drugs with minimal side …

New therapeutic approaches to and mechanisms of ginsenoside Rg1 against neurological diseases

Y Sun, Y Yang, S Liu, S Yang, C Chen, M Lin, Q Zeng… - Cells, 2022 - mdpi.com
Neurological diseases, including Parkinson's disease (PD), Alzheimer's disease (AD),
Huntington's disease (HD), stroke, cerebral infarction, ischemia-reperfusion injury …

Ginsenoside Rb1 as a neuroprotective agent: a review

T Ahmed, SH Raza, A Maryam, WN Setzer… - Brain research …, 2016 - Elsevier
Ginsenosides represent the major bioactive components of ginseng. These triterpenoid
saponins have been shown to exert numerous beneficial effects on the human body. Recent …

Ginsenoside Re exhibits neuroprotective effects by inhibiting neuroinflammation via CAMK/MAPK/NF‑κB signaling in microglia

I Madhi, JH Kim, JE Shin, Y Kim - Molecular Medicine …, 2021 - spandidos-publications.com
Abstract Ginsenoside Re (G‑Re) is a panaxatriol saponin and one of the pharmacologically
active natural constituents of ginseng (Panax ginseng CA Meyer). G‑Re has antioxidant, anti …

[HTML][HTML] A comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system

HJ Kim, P Kim, CY Shin - Journal of ginseng research, 2013 - ncbi.nlm.nih.gov
Ginseng is one of the most widely used herbal medicines in human. Central nervous system
(CNS) diseases are most widely investigated diseases among all others in respect to the …