Advances in the research on the targets of anti-malaria actions of artemisinin

J Yang, Y He, Y Li, X Zhang, YK Wong, S Shen… - Pharmacology & …, 2020 - Elsevier
Malaria has been a global epidemic health threat since ancient times. It still claims roughly
half a million lives every year in this century. Artemisinin and its derivatives, are frontline …

[HTML][HTML] Artemisinin, the magic drug discovered from traditional Chinese medicine

J Wang, C Xu, YK Wong, Y Li, F Liao, T Jiang, Y Tu - Engineering, 2019 - Elsevier
Artemisinin and its derivatives represent the most important and influential class of drugs in
the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global …

The molecular mechanism of action of artemisinin—the debate continues

PM O'Neill, VE Barton, SA Ward - Molecules, 2010 - mdpi.com
Despite international efforts to 'roll back malaria'the 2008 World Malaria Report revealed the
disease still affects approximately 3 billion people in 109 countries; 45 within the WHO …

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

YK Wong, C Xu, KA Kalesh, Y He, Q Lin… - Medicinal research …, 2017 - Wiley Online Library
Artemisinin and its derivatives (collectively termed as artemisinins) are among the most
important and effective antimalarial drugs, with proven safety and efficacy in clinical use …

Discovery, mechanisms of action and combination therapy of artemisinin

L Cui, X Su - Expert review of anti-infective therapy, 2009 - Taylor & Francis
Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Discovery and repurposing of artemisinin

Q Shi, F Xia, Q Wang, F Liao, Q Guo, C Xu, J Wang - Frontiers of medicine, 2022 - Springer
Malaria is an ancient infectious disease that threatens millions of lives globally even today.
The discovery of artemisinin, inspired by traditional Chinese medicine (TCM), has brought in …

A brief history of artemisinin: Modes of action and mechanisms of resistance

LU Feng, HE Xin-Long, C Richard, CAO Jun - Chinese journal of natural …, 2019 - Elsevier
The cornerstone of antimalarial treatment, artemisinin, has reduced malaria associated
morbidity and mortality worldwide. However, Plasmodium falciparum parasites with reduced …

Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production

N Pandey, S Pandey-Rai - Protoplasma, 2016 - Springer
Application of traditional Chinese drug, artemisinin, originally derived from Artemisia annua
L., in malaria therapy has now been globally accepted. Artemisinin and its derivatives, with …

Biological actions of artemisinin: insights from medicinal chemistry studies

J Li, B Zhou - Molecules, 2010 - mdpi.com
Artemisinins have become essential antimalarial drugs for increasingly widespread drug-
resistant malaria strains. Although tremendous efforts have been devoted to decipher how …

Artemisinin and its derivatives; ancient tradition inspiring the latest therapeutic approaches against malaria

E Martino, M Tarantino, M Bergamini… - Future medicinal …, 2019 - Taylor & Francis
Artemisinin (ART) is an endoperoxide sesquiterpene lactone, commonly used in the
treatment of malaria. Although it was isolated from Artemisia annua L., a plant widely applied …