Learning has been associated with modifications of synaptic and circuit properties, but the
precise changes storing information in mammals have remained largely unclear. We …

Memory models often emphasize the need to encode novel patterns of neural activity
imposed by sensory drive. Prior learning and innate architecture likely restrict neural …

Linking neural microcircuit function to emergent properties of the mammalian brain requires
fine-scale manipulation and measurement of neural activity during behavior, where each …

Neurons in the hippocampus exhibit a striking selectivity for specific combinations of sensory
features, forming representations that are thought to subserve episodic memory. Even …

In understanding circuit operations, a key problem is the extent to which neuronal spiking
reflects local computation or responses to upstream inputs. We addressed this issue in the …

Trajectory-dependent splitter neurons in the hippocampus encode information about a
rodent's prior trajectory during performance of a continuous alternation task. As such, they …

Neural network remodeling underpins the ability to remember life experiences, but little is
known about the long-term plasticity of neural populations. To study how the brain encodes …

Hippocampal place cells underlie spatial navigation and memory. Remarkably, CA1
pyramidal neurons can form new place fields within a single trial by undergoing rapid …

To successfully perform goal-directed navigation, animals must know where they are and
what they are doing—eg, looking for water, bringing food back to the nest, or escaping from …

Understanding the mechanisms by which long-term memories are formed and stored in the
brain represents a central aim of neuroscience. Prevailing theory suggests that long-term …