Background Although studies have documented that randomized, controlled trials (RCTs)
have a measurable influence on clinical practice, investigators have uncovered important …

Background The respective roles of generalist and specialist physicians in the care of
patients are currently a matter of debate. Information is limited about the knowledge and …

Background: The impact of clinical trials on medical practice remains controversial, in part
because of weak study designs and nonrepresentative study samples. Objective: To assess …

Background Patients enrolled in randomized clinical trials (RCTs) may not reflect those seen
in real-life practice. Our goal was to compare patients eligible for enrollment but not enrolled …

OBJECTIVE: To review literature relating to significant changes in drug therapy
recommendations in the 1999 American College of Cardiology (ACC)/American Heart …

BACKGROUND: Guidelines for the management of patients with acute myocardial infarction
recommend the routine use of 4 effective cardiac medications: angiotensin-converting …

Background Little is known about the proportion of hospitals in the United States that offer
clinical trial enrollment opportunities and how patient outcomes differ between hospitals that …

Clinicians making treatment decisions are faced with ever-growing numbers of therapies,
each supported by different types of clinical data. By bringing together large amounts of …

Background Many physicians are not adhering to the recommendations found in evidence-
based guidelines for the treatment of acute myocardial infarction (AMI). Physicians who …

Background: There is conclusive evidence from large scale randomized clinical trials (RCTs)
that several treatments administered in the acute phase of a myocardial infarction (AMI) …