There is a considerable body of evidence indicating that chronic adverse experience,
especially chronic psychosocial stress/trauma, represents a major risk factor for the …

Evidence that psychological stress can increase inflammation and worsen the course of
immune-mediated inflammatory disease (IMID) is steadily accumulating. The majority of data …

The aging process is driven by multiple mechanisms that lead to changes in energy
production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality …

Immune functioning decreases with normal aging and with stress. Social and psychological
stressors are a part of daily life and the source of life changing events. Across the lifespan …

The bodies of most animals are populated by highly complex and genetically diverse
communities of microorganisms. The majority of these microbes reside within the intestines …

Highlights•Aging is accompanied by declines in immune function and increases in
inflammation.•Stress in several domains is associated with immunological aging.•Biological …

Research over the past three to four decades has clearly established that psychological
stress affects clinically relevant immune system outcomes, including inflammatory …

The indigenous microbiota impact mucosal, as well as systemic, immune responses, but
whether the microbiota are involved in stressor-induced immunomodulation has not been …

The communication between the central nervous system and the immune system occurs via
a complex network of bidirectional signals linking the nervous, endocrine and immune …

The effect of psychological stress on the gastrointestinal microbiota is widely recognized.
Chronic psychological stress may be associated with increased disease activity in …