[HTML][HTML] Optimization of mesenchymal stromal cell (MSC) manufacturing processes for a better therapeutic outcome

ME Fernández-Santos, M Garcia-Arranz… - Frontiers in …, 2022 - frontiersin.org
MSCs products as well as their derived extracellular vesicles, are currently being explored
as advanced biologics in cell-based therapies with high expectations for their clinical use in …

[HTML][HTML] Biological considerations in scaling up therapeutic cell manufacturing

DS Cherian, T Bhuvan, L Meagher… - Frontiers in …, 2020 - frontiersin.org
Cell therapeutics—using cells as living drugs—have made advances in many areas of
medicine. One of the most clinically studied cell-based therapy products is mesenchymal …

[HTML][HTML] Production of mesenchymal stromal/stem cells according to good manufacturing practices: a review

L Sensebé, M Gadelorge… - Stem cell research & …, 2013 - Springer
Because of their multi/pluripotency and immunosuppressive properties, mesenchymal
stem/stromal cells (MSCs) are important tools for treating immune disorders and for tissue …

[HTML][HTML] The utilization of freezing steps in mesenchymal stromal cell (MSC) manufacturing: potential impact on quality and cell functionality attributes

S Oja, T Kaartinen, M Ahti, M Korhonen… - Frontiers in …, 2019 - frontiersin.org
Some recent reports suggest that cryopreserved and thawed mesenchymal stromal cells
(MSCs) may have impaired functional properties as compared to freshly harvested MSCs …

Standardization of Good Manufacturing Practice–compliant production of bone marrow–derived human mesenchymal stromal cells for immunotherapeutic …

P Wuchter, K Bieback, H Schrezenmeier… - Cytotherapy, 2015 - Elsevier
Background aims Human mesenchymal stem or stromal cells (MSCs) represent a potential
resource not only for regenerative medicine but also for immunomodulatory cell therapies …

Good manufacturing practices production of mesenchymal stem/stromal cells

L Sensebé, P Bourin, K Tarte - Human gene therapy, 2011 - liebertpub.com
Because of their multi/pluripotency and immunosuppressive properties mesenchymal
stem/stromal cells (MSCs) are important tools for treating immune disorders and for tissue …

[HTML][HTML] Towards the standardization of methods of tissue processing for the isolation of mesenchymal stromal cells for clinical use

E García-Muñoz, J Vives - Cytotechnology, 2021 - Springer
Multipotent mesenchymal stromal cells (MSCs) are currently the most extensively studied
type of adult stem cells in advanced stages of development in the field of regenerative …

Mesenchymal stromal cells: from discovery to manufacturing and commercialization

A Mizukami, K Swiech - Stem cells international, 2018 - Wiley Online Library
Over the last decades, mesenchymal stromal cells (MSC) have been the focus of intense
research by academia and industry due to their unique features. MSC can be easily isolated …

[HTML][HTML] Strategies for scalable manufacturing and translation of MSC-derived extracellular vesicles

K Adlerz, D Patel, J Rowley, K Ng, T Ahsan - Stem Cell Research, 2020 - Elsevier
Abstract Mesenchymal Stem/Stromal Cells (MSCs) are a well-studied cellular therapy with
many clinical trials over the last few decades to treat a range of therapeutic indications …

[HTML][HTML] Bioprocessing strategies for the large-scale production of human mesenchymal stem cells: a review

KM Panchalingam, S Jung, L Rosenberg… - Stem cell research & …, 2015 - Springer
Human mesenchymal stem cells (hMSCs), also called mesenchymal stromal cells, have
been of great interest in regenerative medicine applications because of not only their …