A major challenge in the field of neurodegenerative diseases and brain aging is to identify
the body's intrinsic mechanism that could sense the central nervous system (CNS) damage …

Brain macrophage populations include parenchymal microglia, border-associated
macrophages, and recruited monocyte-derived cells; together, they control brain …

Microglia and macrophages are pivotal to the brain's innate immune response and have
garnered considerable attention in the context of glioblastoma (GBM) and Alzheimer's …

In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress
are central events. Recent genome-wide transcriptomic analyses of microglial cells under …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and is closely
associated with the accumulation of β-amyloid (Aβ) and neurofibrillary tangles (NFTs). Apart …

Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective
treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD …

Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key
signaling steps of innate immune activation hence represent promising therapeutic targets …

The neuroimmune system is involved in development, normal functioning, aging, and injury
of the central nervous system. Microglia, first described a century ago, are the main …

Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …

Microglia contribute to development, homeostasis, and immunity of the CNS. Like other
tissue-resident macrophage populations, microglia express the surface receptor triggering …