[HTML][HTML] Overactivation of IL6 cis‑signaling in leukocytes is an inflammatory hallmark of deep vein thrombosis

R Salemi, B Tomasello, G Gattuso… - Molecular …, 2022 - spandidos-publications.com
Inflammation is a protective response of the body to various injuries, which is strictly
regulated by a variety of factors, including immune cells and soluble mediators. However …

[HTML][HTML] Co-occurrence of interleukin-6 receptor Asp358Ala variant and high plasma levels of IL-6: an evidence of IL-6 trans-signaling activation in deep vein …

R Salemi, G Gattuso, B Tomasello, A Lavoro, A Gaudio… - Biomolecules, 2022 - mdpi.com
Interleukin-6 (IL-6) is a pleiotropic cytokine involved in several mechanisms, and the
alteration of IL-6 signaling leads to the overactivation of various processes including …

IL-17A promotes the formation of deep vein thrombosis in a mouse model

P Ding, S Zhang, M Yu, Y Feng, Q Long, H Yang… - International …, 2018 - Elsevier
Deep venous thrombosis (DVT) is a significant problem in the health care industry
worldwide. However, the factors and signaling pathways that trigger DVT formation are still …

[HTML][HTML] IL-9 promotes the development of deep venous thrombosis by facilitating platelet function

Y Feng, M Yu, F Zhu, S Zhang, P Ding… - Thrombosis and …, 2018 - thieme-connect.com
The development of deep venous thrombosis (DVT) is a sterile inflammatory process related
to cytokines, such as interleukin (IL)-6 or IL-17. IL-9 is a cytokine involved in many …

IL (Interleukin)-6 contributes to deep vein thrombosis and is negatively regulated by miR-338-5p

Y Zhang, Z Zhang, R Wei, X Miao, S Sun… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Deep venous thrombosis (DVT), one of the most common venous
thromboembolic disorders, is closely linked with pulmonary embolism and post-thrombotic …

[HTML][HTML] Correlation between the expression of IL‑18 and deep venous thrombosis Corrigendum in/10.3892/ijmm. 2018.3843

G Li, R Zhou, X Zhao, R Liu… - … Journal of Molecular …, 2018 - spandidos-publications.com
The present study aimed to investigate the effect of the expression of interleukin (IL)‑18 and
related markers on deep venous thrombosis (DVT) to examine their correlation. Sprague …

[HTML][HTML] Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial …

MM Zegeye, M Lindkvist, K Fälker, AK Kumawat… - Cell Communication and …, 2018 - Springer
Background IL-6 classic signaling is linked to anti-inflammatory functions while the trans-
signaling is associated with pro-inflammatory responses. Classic signaling is induced via …

[HTML][HTML] Modulation of interleukin-6 and its effect on late vein wall injury in a stasis mouse model of deep vein thrombosis

AR Dowling, CE Luke, Q Cai, AM Pellerito, AT Obi… - JVS-Vascular …, 2022 - Elsevier
Objective Deep vein thrombosis (DVT) and its sequela, post-thrombotic syndrome (PTS),
remain a clinically significant problem. Interleukin-6 (IL-6) is a proinflammatory cytokine that …

Global transcriptional profiling reveals novel autocrine functions of interleukin 6 in human vascular endothelial cells

LU Ljungberg, MM Zegeye, C Kardeby… - Mediators of …, 2020 - Wiley Online Library
Background. Interleukin 6 (IL6) is a multifunctional cytokine produced by various cells,
including vascular endothelial cells. IL6 has both pro‐and non‐/anti‐inflammatory functions …

Interleukin‐17A Exacerbates Ferric Chloride‐Induced Arterial Thrombosis in Rat Carotid Artery

F Maione, A Parisi, E Caiazzo, S Morello… - International Journal …, 2014 - Wiley Online Library
Interleukin‐17A (IL‐17A), the most widely studied member of the IL‐17 cytokine family, is a
cytokine which emerged to be critical for host defense as well as in the pathogenesis of …