A Hybrid Hydrogel with Intrinsic Immunomodulatory Functionality for Treating Multidrug-Resistant Pseudomonas aeruginosa Infected Diabetic Foot Ulcers

X Qi, Y Shi, C Zhang, E Cai, XX Ge, Y Xiang… - ACS Materials …, 2024 - ACS Publications
Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs)
are predominantly nonspecific. These IDFU injuries often display prolonged inflammation …

Immunomodulatory gallium/glycyrrhizic acid hydrogels for treating multidrug-resistant Pseudomonas aeruginosa-infected pressure ulcers

C Zhang, E Cai, X Qi, XX Ge, Y Xiang, J Wang… - Chemical Engineering …, 2024 - Elsevier
Current approaches to treating infected pressure ulcers (IPUs) tend to lack specificity. Such
injuries frequently exhibit extended inflammation and slow tissue regeneration, largely due …

An Immunoregulation Hydrogel with Controlled Hyperthermia‐Augmented Oxygenation and ROS Scavenging for Treating Diabetic Foot Ulcers

X Qi, XX Ge, X Chen, E Cai, Y Xiang… - Advanced Functional …, 2024 - Wiley Online Library
Diabetic foot ulcers (DFUs), a serious and increasingly common chronic issue among
diabetics, often do not respond well to generalized treatment strategies. Hypoxia and the …

Immunomodulatory hydrogels: advanced regenerative tools for diabetic foot ulcer

Y Xiong, Q Feng, L Lu, K Zha, T Yu, Z Lin… - Advanced Functional …, 2023 - Wiley Online Library
Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing
physical and mental challenges for patients due to the lack of efficient curative therapy …

Bioactive injectable hydrogel dressings for bacteria-infected diabetic wound healing: a “pull–push” approach

K Zhang, C Yang, C Cheng, C Shi, M Sun… - … applied materials & …, 2022 - ACS Publications
Chronic diabetic wound healing remains a challenge due to the existence of excessive
danger molecules and bacteria in the inflammatory microenvironment. There is an urgent …

Immunoregulation in diabetic wound repair with a photoenhanced glycyrrhizic acid hydrogel scaffold

Y Qian, Y Zheng, J Jin, X Wu, K Xu, M Dai… - Advanced …, 2022 - Wiley Online Library
M1 macrophage accumulation and excessive inflammation are commonly encountered
issues in diabetic wounds and can fail in the healing process. Hence, hydrogel dressings …

Nanoenzyme-reinforced injectable hydrogel for healing diabetic wounds infected with multidrug resistant bacteria

S Wang, H Zheng, L Zhou, F Cheng, Z Liu, H Zhang… - Nano …, 2020 - ACS Publications
Diabetic wound healing remains a critical challenge due to its vulnerability to multidrug-
resistant (MDR) bacterial infection, as well as the hyperglycemic and oxidative wound …

Dual-function hydrogel dressings with a dynamic exchange of Iron ions and an antibiotic drug for treatment of infected wounds

I Pilipenko, A Murzova, A Savin… - ACS Applied Bio …, 2023 - ACS Publications
Bacterial infection is a major problem with diabetic wounds that may result in nonhealing
chronic ulcers. Here, we report an approach to antibacterial hydrogel dressings for …

Biomimetic Nanozyme-Decorated Hydrogels with H2O2-Activated Oxygenation for Modulating Immune Microenvironment in Diabetic Wound

Y Zhao, D Wang, T Qian, J Zhang, Z Li, Q Gong… - ACS …, 2023 - ACS Publications
Diabetic foot ulcers (DFUs) remain a devastating threat to human health. While hydrogels
are promising systems for DFU-based wound management, their effectiveness is often …

[HTML][HTML] Antibacterial coaxial hydro-membranes accelerate diabetic wound healing by tuning surface immunomodulatory functions

W Zhang, S Xia, T Weng, M Yang, J Shao, M Zhang… - Materials Today Bio, 2022 - Elsevier
Diabetic foot ulcers, typical non-healing wounds, represent a severe clinical problem.
Advanced glycation end-products (AGEs), which create a prolonged pro-inflammatory micro …