Adenosine (Ado) accumulates in tissues under metabolic stress. On myocardial cells, the
nucleoside interacts with various receptor subtypes (A1, A3, and probably A2A and A2B) …

Adenosine, a purine nucleoside, is ubiquitous in the body, and is a critical component of
ATP. Its concentration jumps 100-fold during periods of oxygen depletion and ischemia …

Adenosine is a purine nucleoside, which is produced primarily through the metabolism of
adenosine triphosphate (ATP), therefore its levels increase during stressful situations when …

Adenosine, formed primarily via hydrolysis of 5′-AMP, has been historically dubbed a
“retaliatory” metabolite due to enhanced local release and beneficial actions during …

Adenosine, a catabolite of ATP, exerts numerous effects in the heart, including modulation of
the cardiac response to stress, such as that which occurs during myocardial ischemia and …

Ischemic heart disease includes a number of entities that have been grouped in accordance
with physiopathology and evolutive criteria. In recent years 'new'ischemic syndromes have …

Endogenous adenosine is produced by the heart during ischemia-reperfusion as a natural
cardioprotectant. The benefits of this local protective mechanism can be harnessed by …

Cells of the cardiovascular system generate and release purine nucleoside adenosine in
increasing quantities when constituent cells are “stressed” or subjected to injurious stimuli …

Ischemia-reperfusion results in contractile dysfunction, necrosis, and vascular injury. This
postischemic injury is mediated in part by superoxide radical production, neutrophils …

Adenosine, a metabolite of ATP, serves a number of important physiological roles in the
body. These actions contribute to sedation, bradycardia, vasorelaxation, inhibition of …