SARS-CoV-2 infection in hamsters and humans results in lasting and unique systemic perturbations after recovery

JJ Frere, RA Serafini, KD Pryce, M Zazhytska… - Science translational …, 2022 - science.org
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection can result in prolonged pathologies collectively referred to as post-acute sequalae …

In vitro and animal models for SARS-CoV-2 research

K Takayama - Trends in pharmacological sciences, 2020 - cell.com
Basic research on SARS-CoV-2 is essential to understand its detailed pathophysiology and
identify best drug targets. Models that can faithfully reproduce the viral life cycle and …

[HTML][HTML] Animal models in SARS-CoV-2 research

H Chu, JFW Chan, KY Yuen - Nature methods, 2022 - nature.com
Animal models in SARS-CoV-2 research | Nature Methods Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathology

SJ Cleary, SC Pitchford, RT Amison… - British journal of …, 2020 - Wiley Online Library
The coronavirus disease 2019 (COVID‐19) pandemic caused by SARS‐CoV‐2 infections
has led to a substantial unmet need for treatments, many of which will require testing in …

[HTML][HTML] SARS-CoV-2 infection in the mouse olfactory system

Q Ye, J Zhou, Q He, RT Li, G Yang, Y Zhang, SJ Wu… - Cell discovery, 2021 - nature.com
SARS-CoV-2 infection causes a wide spectrum of clinical manifestations in humans, and
olfactory dysfunction is one of the most predictive and common symptoms in COVID-19 …

Human Nasal and Lung Tissues Infected Ex Vivo with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in …

O Alfi, A Yakirevitch, O Wald, O Wandel, U Izhar… - Journal of …, 2021 - Am Soc Microbiol
The nasal mucosa constitutes the primary entry site for respiratory viruses, including severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While the imbalanced innate …

[HTML][HTML] SARS-CoV-2 causes a systemically multiple organs damages and dissemination in hamsters

Z Song, L Bao, P Yu, F Qi, S Gong, J Wang… - Frontiers in …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread across the
world and impacted global healthcare systems. For clinical patients, COVID-19 not only …

Animal models for emerging coronavirus: progress and new insights

L Yuan, Q Tang, T Cheng, N Xia - Emerging Microbes & Infections, 2020 - Taylor & Francis
The emergences of coronaviruses have caused a serious global public health problem
because their infection in humans caused the severe acute respiratory disease and deaths …

[HTML][HTML] Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

G Nouailles, E Wyler, P Pennitz, D Postmus… - Nature …, 2021 - nature.com
In COVID-19, immune responses are key in determining disease severity. However, cellular
mechanisms at the onset of inflammatory lung injury in SARS-CoV-2 infection, particularly …

[HTML][HTML] Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling

JS Bednash, VE Kagan, JA Englert, D Farkas… - Translational …, 2022 - Elsevier
The acute respiratory distress syndrome (ARDS) is a common complication of severe COVID-
19 (coronavirus disease 2019) caused by SARS-CoV-2 (severe acute respiratory syndrome …