Background In inflamed tissue, immune cells are accumulated, and various intercellular
signals are involved in the pathogenesis. Janus kinases (JAKs) are typical tyrosine kinases …

We are witnessing a paradigm shift in drug development and clinical practice to fight the
novel coronavirus disease (COVID-19), and a number of clinical trials have been or are …

Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine
storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been …

JAK inhibitors are novel treatment agents in the field of infectious diseases. One JAK
inhibitor, baricitinib has demonstrated significant clinical and survival benefits in hospitalized …

Background With potential antiviral and anti‐inflammatory properties, Janus kinase (JAK)
inhibitors represent a potential treatment for symptomatic severe acute respiratory syndrome …

Background Currently, JAK-inhibitors are repurposed for therapy of Covid-19 because of
their ability in restraining immune response, yet the corroboration regarding their advantage …

Objectives This systematic review and meta-analysis of randomized controlled trials (RCTs)
aimed to investigate the clinical efficacy and safety of Janus kinase (JAK) inhibitors for …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic continues to
spread globally. The rapid dispersion of coronavirus disease 2019 (COVID-19) caused by …

Background: Cytokine storm observed in severe Coronavirus Disease 2019 (COVID-19)
patients contributes to poor clinical outcomes and increased mortality. We aim to conduct a …

Abstract Coronavirus disease-2019 (COVID-19) represents a global public health
nightmare. The “cytokine storm,” the most prominent underlying pathophysiologic …