[HTML][HTML] Aged population and immunocompromised patients: impact on SARS-CoV-2 variants and treatment outcomes

VP Chavda, MT Chhabria, V Apostolopoulos - Biologics, 2022 - mdpi.com
Patients with an immunocompromised state are at risk of developing a long-term infection
from the coronavirus 2 that causes severe acute respiratory syndrome (SARS-CoV-2). It has …

Immune response to COVID-19 in older adults

M Jergović, CP Coplen, JL Uhrlaub… - The Journal of Heart and …, 2021 - Elsevier
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the third highly
pathogenic coronavirus to emerge in the human population in last two decades. SARS-CoV …

[HTML][HTML] Patients with moderate to severe COVID-19 have an impaired cytokine response with an exhausted and senescent immune phenotype

AD Dhanda, D Felmlee, P Boeira, P Moodley… - …, 2022 - ncbi.nlm.nih.gov
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV2), is asymptomatic or mild in most but leads to moderate or …

[HTML][HTML] Long COVID: the nature of thrombotic sequelae determines the necessity of early anticoagulation

C Wang, C Yu, H Jing, X Wu, VA Novakovic… - Frontiers in Cellular …, 2022 - frontiersin.org
Many discharged COVID-19 patients affected by sequelae experience reduced quality of life
leading to an increased burden on the healthcare system, their families and society at large …

The impact of aging and COVID-19 on our immune system: a high-resolution map from single cell analysis

J Yang, H Li - Protein & cell, 2020 - academic.oup.com
One key aspect of human aging is the dysregulation of the immune system. As we age, our
body's defense system weakens, leading to declined responses to infection by new …

[HTML][HTML] SARS-CoV-2 infection in fully vaccinated individuals of old age strongly boosts the humoral immune response

L Müller, M Andrée, PN Ostermann, N Jazmati… - Frontiers in …, 2021 - frontiersin.org
Prophylactic vaccination against SARS-CoV-2 is one of the most important measures to
contain the COVID-19 pandemic. Recently, break-through infections following vaccination …

[HTML][HTML] Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia

D Lo Tartaro, A Neroni, A Paolini, R Borella… - Communications …, 2022 - nature.com
Aging is a major risk factor for developing severe COVID-19, but few detailed data are
available concerning immunological changes after infection in aged individuals. Here we …

COVID-19 and Long-COVID Thrombosis: From Clinical and Basic Science to Therapeutics

F Violi, J Harenberg, P Pignatelli… - Thrombosis and …, 2023 - thieme-connect.com
Coronavirus infectious disease-19 (COVID-19) is a pandemic characterized by serious lung
disease and thrombotic events in the venous and circulation trees, which represent a …

[HTML][HTML] SARS-CoV-2 variants in patients with immunosuppression

L Corey, C Beyrer, MS Cohen… - … England Journal of …, 2021 - Mass Medical Soc
SARS-CoV-2 Variants in Patients with Immunosuppression | NEJM Skip to main content NEJM
Group Follow Us Facebook Twitter Instagram YouTube LinkedIn Prepare to become a …

The effects of aging on host resistance and disease tolerance to SARS‐CoV‐2 infection

DZL Mok, CYY Chan, EE Ooi, KR Chan - The FEBS Journal, 2021 - Wiley Online Library
The ongoing coronavirus disease 2019 (COVID‐19) crisis caused by severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has triggered a large‐scale pandemic …