Androgen insensitivity describes the inability of cells to respond adequately to androgens.
The clinical aspects are well characterized and described in the androgen insensitivity …

Androgen action is mediated in the peripheral target cell via the androgen receptor (AR).
The AR is a nuclear transcription factor, combining a DNA-binding and a hormone-binding …

The androgen receptor belongs to the family of steroid-tyroid hormone-retinoid nuclear
receptors. It contains 3 major domains: a hormone-binding region, a DNA-binding region …

The androgen insensitivity syndrome is a disorder caused by deficient function of the
androgen receptor, characterized by varying degrees of undermasculinization in karyotypic …

Mutations in the X-linked androgen receptor (AR) gene cause the androgen insensitivity
syndrome by impairing androgen-dependent male sexual differentiation to varying degrees …

The androgen receptor (AR) is a high affinity receptor protein encoded on the human X-
chromosome that mediates the actions of androgens during development and in the adult …

Male sexual differentiation and development proceed under direct control of androgens.
Androgen action is mediated by the intracellular androgen receptor, which belongs to the …

Androgen insensitivity syndrome (AIS) is a disorder of male sexual development which
includes a wide spectrum of phenotypic abnormalities in 46, XY individuals ranging from …

Androgen resistance causes the androgen insensitivity syndrome in its variant forms and is
a paradigm of clinical syndromes associated with hormone resistance. In its complete form …

The end-organ resistance to androgens has been designated as Androgen Insensitivity
Syndrome (AIS), an X-linked disorder caused by mutations in the Androgen Receptor (AR) …