Computer-assisted design of peptide-based radiotracers

V Patamia, C Zagni, I Brullo, E Saccullo… - International Journal of …, 2023 - mdpi.com
In medical imaging, techniques such as magnetic resonance imaging, contrast-enhanced
computerized tomography, positron emission tomography (PET), and single-photon …

In silico modelling in the development of novel radiolabelled peptide probes

J Kleynhans, HG Kruger, T Cloete… - Current Medicinal …, 2020 - ingentaconnect.com
This review describes the usefulness of in silico design approaches in the design of new
radiopharmaceuticals, especially peptide-based radiotracers (including peptidomimetics) …

Peptide-based positron emission tomography probes: Current strategies for synthesis and radiolabelling

M Failla, G Floresta, V Abbate - RSC Medicinal Chemistry, 2023 - pubs.rsc.org
In medical imaging, techniques such as magnetic resonance imaging, contrast-enhanced
computerized tomography, and positron emission tomography (PET) are extensively …

Clinical applications of radiolabeled peptides for PET

IM Jackson, PJH Scott, S Thompson - Seminars in Nuclear Medicine, 2017 - Elsevier
Radiolabeled peptides are a valuable class of radiotracer that occupies the space between
small molecules and large biologics, and are able to exploit the advantages of both classes …

Radiolabelled peptides in medical imaging

SM Okarvi, HR Maecke - Peptide applications in biomedicine …, 2018 - Elsevier
Regulatory peptides—naturally occurring peptide molecules, with a size of usually less than
30 amino acids—play vital roles in all living systems and are responsible for many essential …

Design, synthesis and preclinical evaluation of radiolabeled peptides for diagnosis and therapy

L Aloj, G Morelli - Current pharmaceutical design, 2004 - ingentaconnect.com
Recent years have seen an increased effort in the development of peptide based
radiopharmaceuticals for nuclear medicine applications in imaging and therapy. This field is …

Artificial intelligence and the future of diagnostic and therapeutic radiopharmaceutical development: in silico smart molecular design

B Ataeinia, P Heidari - PET clinics, 2021 - pet.theclinics.com
Radiopharmaceuticals play a pivotal role in the rapidly emerging field of personalized
medicine. 1 In disease states, altered expression or aggregation of specific molecules allow …

Structural modifications of amino acid sequences of radiolabeled peptides for targeted tumor imaging

F Maleki, AM Farahani, F Rezazedeh… - Bioorganic chemistry, 2020 - Elsevier
Molecular imaging techniques are increasingly being used in localization, staging and
therapy control of cancer. Due to their unique target specificity for the endogenous receptors …

Methods to enhance the metabolic stability of peptide-based PET radiopharmaceuticals

BJ Evans, AT King, A Katsifis, L Matesic, JF Jamie - Molecules, 2020 - mdpi.com
The high affinity and specificity of peptides towards biological targets, in addition to their
favorable pharmacological properties, has encouraged the development of many peptide …

Radiolabeled peptide probe for tumor imaging

YQ Yan, H Wang, Y Zhao - Chinese Chemical Letters, 2022 - Elsevier
Radionuclide imaging is now the premier imaging method in clinical practice for its high
sensitivity and tomographic capability. Current clinically available radio imaging methods …