Despite the large toll of opioid use disorder (OUD), genome-wide association studies
(GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale …

The growing prevalence of opioid use disorder (OUD) constitutes an urgent health crisis.
Ample evidence indicates that risk for OUD is heritable. As a surrogate (or proxy) for OUD …

To provide insights into the biology of opioid dependence (OD) and opioid use (ie,
exposure, OE), we completed a genome-wide analysis comparing 4503 OD cases, 4173 …

Highlights•Opioid use disorder risk has a large heritable component (23–54%).•The OPRM1
variant rs1799971 (aka A118G) as a small effect on risk for OUD and general substance …

Despite an estimated heritability of~ 50%, genome-wide association studies of opioid use
disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross …

Genetic liability to substance use disorders can be parsed into loci that confer general or
substance-specific addiction risk. We report a multivariate genome-wide association meta …

Background We report a genome-wide association study (GWAS) of two populations, African-
American and European-American (AA, EA) for opioid dependence (OD) in three sets of …

Substance use disorders (SUD) are a major contributor to disability and disease burden
worldwide. Risk for developing SUDs is influenced by variation in the genome. Identifying …

Importance With the current opioid crisis, it is important to improve understanding of the
biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk …

Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in
OPRM1, has been identified as a genome-wide significant association with OA and …