Regulatory T cells (Treg) are a subpopulation of T cells that maintain tolerance to self and
limit other immune responses. They achieve this through different mechanisms including the …

Summary Foxp3+ T regulatory (Treg) cells prevent inflammatory disease but the mechanistic
basis of suppression is not understood completely. Gene silencing by RNA interference can …

In order to maintain immunological tolerance to self and non-self antigens, one's T
regulatory (Treg) cells play a critical role in the regulation of detrimental inflammation. Treg …

The immune system is composed of different cell types localised throughout the organism to
sense and respond to pathological situations while maintaining homeostasis under …

Upon T cell receptor stimulation, CD4+ T helper (Th) lymphocytes release extracellular
vesicles (EVs) containing microRNAs. However, no data are available on whether human …

Dendritic cells (DCs) are the most potent APCs. Whereas immature DCs down-regulate T-
cell responses to induce/maintain immunologic tolerance, mature DCs promote immunity. To …

The discovery of microRNA (miRNA) sorting into extracellular vesicles (EVs) revealed a
novel mode of intercellular communication and uncovered a link between cellular …

Exosomes are extracellular vesicles released by many cells of the body. These small
vesicles play an important part in intercellular communication both in the local environment …

Extracellular communication, in other words, crosstalk between cells, has a pivotal role in
the survival of an organism. This communication occurs by different methods, one of which is …

Extracellular vehicles (EVs) are efficient biomarkers of disease and participate in disease
pathogenesis; however, their use as clinical therapies to modify disease outcomes remains …