Plasmodium falciparum Merozoite Surface Antigen, PfRH5, Elicits Detectable Levels of Invasion-Inhibiting Antibodies in Humans
Plasmodium falciparum is an intracellular protozoan parasite that infects erythrocytes and
hepatocytes. The blood stage of its life cycle causes substantial morbidity and mortality …
hepatocytes. The blood stage of its life cycle causes substantial morbidity and mortality …
[HTML][HTML] Enhancing Blockade of Plasmodium falciparum Erythrocyte Invasion: Assessing Combinations of Antibodies against PfRH5 and Other Merozoite Antigens
AR Williams, AD Douglas, K Miura, JJ Illingworth… - PLoS …, 2012 - journals.plos.org
No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum,
which cause the symptoms and severe manifestations of malaria. We recently found that …
which cause the symptoms and severe manifestations of malaria. We recently found that …
[HTML][HTML] Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains
T Triglia, L Chen, S Lopaticki, C Dekiwadia… - PLoS …, 2011 - journals.plos.org
Plasmodium falciparum, the causative agent of the most severe form of malaria in humans
invades erythrocytes using multiple ligand-receptor interactions. The P. falciparum …
invades erythrocytes using multiple ligand-receptor interactions. The P. falciparum …
A New Rodent Model to Assess Blood Stage Immunity to the Plasmodium falciparum Antigen Merozoite Surface Protein 119 Reveals a Protective Role for Invasion …
TF de Koning-Ward, RA O'Donnell, DR Drew… - The Journal of …, 2003 - rupress.org
Antibodies capable of inhibiting the invasion of Plasmodium merozoites into erythrocytes are
present in individuals that are clinically immune to the malaria parasite. Those targeting the …
present in individuals that are clinically immune to the malaria parasite. Those targeting the …
Bacterially expressed full-length recombinant Plasmodium falciparum RH5 protein binds erythrocytes and elicits potent strain-transcending parasite-neutralizing …
Plasmodium falciparum reticulocyte binding-like homologous protein 5 (PfRH5) is an
essential merozoite ligand that binds with its erythrocyte receptor, basigin. PfRH5 is an …
essential merozoite ligand that binds with its erythrocyte receptor, basigin. PfRH5 is an …
[HTML][HTML] A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys
AD Douglas, GC Baldeviano, CM Lucas… - Cell host & …, 2015 - cell.com
Antigenic diversity has posed a critical barrier to vaccine development against the
pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To …
pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To …
[HTML][HTML] Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria
CYH Chiu, J Healer, JK Thompson, L Chen… - Frontiers in …, 2014 - frontiersin.org
Emerging evidence suggests that antibodies against merozoite proteins involved in
Plasmodium falciparum invasion into the red blood cell (RBC) play an important role in …
Plasmodium falciparum invasion into the red blood cell (RBC) play an important role in …
[HTML][HTML] A malaria vaccine candidate based on an epitope of the Plasmodium falciparum RH5 protein
RL Ord, JC Caldeira, M Rodriguez, A Noe… - Malaria journal, 2014 - Springer
Abstract Background The Plasmodium falciparum protein RH5 is an adhesin molecule
essential for parasite invasion of erythrocytes. Recent studies show that anti-PfRH5 sera …
essential for parasite invasion of erythrocytes. Recent studies show that anti-PfRH5 sera …
[HTML][HTML] The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
AD Douglas, AR Williams, JJ Illingworth… - Nature …, 2011 - nature.com
Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are
mostly focused on well-studied merozoite antigens that induce immune responses after …
mostly focused on well-studied merozoite antigens that induce immune responses after …
[HTML][HTML] Human antibodies that slow erythrocyte invasion potentiate malaria-neutralizing antibodies
DGW Alanine, D Quinkert, R Kumarasingha… - Cell, 2019 - cell.com
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading
target for next-generation vaccines against the disease-causing blood-stage of malaria …
target for next-generation vaccines against the disease-causing blood-stage of malaria …