Systemic autoimmune diseases (SAIDs), such as systemic lupus erythematosus (SLE),
systemic sclerosis (SSc) and rheumatoid arthritis (RA), are fully related to the unregulated …

Abstract Chimeric Antigen Receptor T-cell therapy (CAR-T), currently employed routinely for
treating B-cell malignancies, has emerged as a groundbreaking approach in addressing …

The immune system is the body's main line of defense against invasion by infectious
organisms, such as bacteria, virus, and fungi. In normal immune systems, an immune …

In a recent study from NEJM, Mougiakakos et al. reported a case in which autologous anti-
CD19 CAR-T cell therapy was used in the treatment of a refractory SLE patient [1]. Rapid …

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder
resulting from autoantibodies produced by B-cell derived plasma cells. Clinical presentation …

Introduction Despite advancements in managing autoimmune rheumatic diseases (ARDs)
with existing treatments, many patients still encounter challenges such as inadequate …

CAR (Chimeric Antigen Receptor) T-cell therapy has revolutionized the field of oncology in
recent years. This innovative shift in cancer treatment also provides the opportunity to …

Autoimmune diseases are a result of the immune system being misdirected toward its host
and have major and increasing unmet clinical needs. In general, present therapies are …

Systemic lupus erythematosus (SLE) is a chronic autoimmune illness with an unclear
etiology and a range of clinical manifestations. The therapeutic results of current …

CAR T cells induce remission in a patient with refractory SLE | Nature Reviews Rheumatology
Skip to main content Thank you for visiting nature.com. You are using a browser version with …