Yearning for machine learning: applications for the classification and characterisation of senescence
BK Hughes, R Wallis, CL Bishop - Cell and Tissue Research, 2023 - Springer
Senescence is a widely appreciated tumour suppressive mechanism, which acts as a barrier
to cancer development by arresting cell cycle progression in response to harmful stimuli …
to cancer development by arresting cell cycle progression in response to harmful stimuli …
A guide to assessing cellular senescence in vitro and in vivo
Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …
[HTML][HTML] A blueprint for characterizing senescence
AL Roy, F Sierra, K Howcroft, DS Singer, N Sharpless… - Cell, 2020 - cell.com
Given the heterogeneity of senescent cells, our knowledge of both the drivers and
consequences of cellular senescence in tissues and organs remains limited, as is our …
consequences of cellular senescence in tissues and organs remains limited, as is our …
Comprehensive assessment of cellular senescence in the tumor microenvironment
Cellular senescence (CS), a state of permanent growth arrest, is intertwined with
tumorigenesis. Due to the absence of specific markers, characterizing senescence levels …
tumorigenesis. Due to the absence of specific markers, characterizing senescence levels …
Unmasking transcriptional heterogeneity in senescent cells
Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …
Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators
W Tao, Z Yu, JDJ Han - Cell Metabolism, 2024 - cell.com
Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses
challenges for studying and targeting senescent cells. We present here a machine learning …
challenges for studying and targeting senescent cells. We present here a machine learning …
Cellular senescence: defining a path forward
Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …
The heterogeneity of cellular senescence: insights at the single-cell level
Senescent cells are highly associated with aging and pathological conditions and could be
targeted to slow the aging process. One commonly used marker to examine senescent cells …
targeted to slow the aging process. One commonly used marker to examine senescent cells …
Machine learning-based morphological quantification of replicative senescence in human fibroblasts
EM Welter, S Benavides, TK Archer, O Kosyk… - GeroScience, 2024 - Springer
Although aging has been investigated extensively at the organismal and cellular level, the
morphological changes that individual cells undergo along their replicative lifespan have not …
morphological changes that individual cells undergo along their replicative lifespan have not …
Detection of senescence using machine learning algorithms based on nuclear features
Cellular senescence is a stress response with broad pathophysiological implications.
Senotherapies can induce senescence to treat cancer or eliminate senescent cells to …
Senotherapies can induce senescence to treat cancer or eliminate senescent cells to …