Chitosan (CS) is a hemi-synthetic cationic linear polysaccharide produced by the
deacetylation of chitin. CS is non-toxic, highly biocompatible, and biodegradable, and it has …

Introduction: A major problem in ocular therapeutics with classical formulations is the
maintenance of an effective drug concentration at the site of action for a long period of time …

From the past few decades, tremendous awareness has been laid on the use of natural
polymers in ocular drug delivery. Chitosan, a modified natural carbohydrate polymer, has …

The main inconvenience of conventional eye drops is the rapid washout of the drugs due to
nasolacrimal drainage or ophthalmic barriers. The ocular drug bioavailability can be …

This paper presents an overview of the potential of chitosan‐based systems for improving
the retention and biodistribution of drugs applied topically onto the eye. Besides its low …

Nanoscience and nanotechnology has caused important breakthroughs in different
therapeutic areas. In particular, the application of nanotechnology in ophthalmology has led …

The purpose of this review is to provide the reader with an overview of the advances made
in ocular delivery of bioactive molecules by means of chitosan-based nanosystems, and …

Purpose The goal of the present study was to synthesize mucoadhesive polymer–thiolated
chitosan (TCS) from chitosan (CS), then prepared CS/TCS-sodium alginate nanoparticles …

Purpose. To assess the potential of chitosan (CS) nanoparticles for ocular drug delivery by
investigating their interaction with the ocular mucosa in vivo and also their toxicity in …

Eyes are directly exposed to the outer environment and susceptible to infections, leading to
various ocular disorders. Local medication is preferred to treat eye diseases due to its …