Iron is indispensable for normal body functions across species because of its critical roles in
red blood cell function and many essential proteins and enzymes required for numerous …

Aging is associated with disturbances in iron metabolism and storage. During the last
decade, remarkable progress has been made toward understanding their cellular and …

Iron is a trace metal element necessary to maintain life and is also involved in a variety of
biological processes. Aging refers to the natural life process in which the physiological …

While there have been significant advances made in our understanding of the cellular and
molecular mechanisms that regulate iron absorption, transport, storage, and utilization, the …

Iron is an essential element for virtually all living organisms, but its reactivity also makes it
potentially harmful. Iron accumulates with aging, and is associated with many age-related …

Recent studies show that cellular and mitochondrial iron increases with age. Iron overload,
especially in mitochondria, increases the availability of redox-active iron, which may be a …

Handling a life‐supporting yet redox‐active metal like iron represents a significant challenge
to cells and organisms that must not only tightly balance intra‐and extracellular iron …

Iron is necessary for life but also a potent pro-oxidant implicated in the pathogenesis of age-
related diseases. We sought to determine if iron levels change with age and by sex in …

Brain iron is tightly regulated by a multitude of proteins to ensure homeostasis. Iron
dyshomeostasis has become a molecular signature associated with aging which is …

Background Iron is essential for many types of biological processes. However, excessive
iron can be cytotoxic and can lead to many diseases. Since ferroptosis, which is an iron …