Various genes are known to modulate the delicate balance of dopamine in prefrontal cortex
and influence cortical information processing. Catechol-O-methyltransferase (COMT) on …

The Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene may be
related to individual differences in cognition, likely via modulation of prefrontal dopamine …

Studies in children have shown that the genetic influence on cognition is positively
correlated with socioeconomic status. Catechol‐O‐methyltransferase (COMT) Val158Met, a …

Genetic variation in catechol-O-methyltransferase (COMT), encoding an enzyme critical for
prefrontal dopamine flux, has been studied extensively using both behavioral and …

The catechol-O-methyltransferase (COMT) gene has attracted strong neuroscientific interest
due to its implication in dopaminergic neurotransmission. One of its most widely studied …

Catechol-O-methyltransferase (COMT) is a promising target for modulation of cognitive
functions and dysfunctions. COMT dominates the regulation of dopamine metabolism in the …

Catechol-O-methyltransferase (COMT) modulates dopamine in the prefrontal cortex (PFC)
and influences PFC dopamine-dependent cognitive task performance. A human COMT …

Behavioral phenotypes are generally complex, reflecting the action of multiple different
genes. Nevertheless, there is growing evidence that key gene variants can alter activity …

Catechol-O-methyl transferase (COMT) val 108/158 met polymorphism impacts on cortical
dopamine levels and may influence functional magnetic resonance (fMRI) measures of task …

BACKGROUND: Cognitive endophenotypes may further our understanding of the genetic
basis of psychiatric disorders, and the catechol-O-methyltransferase (COMT) gene is a …