Blood urea nitrogen and serum creatinine are imperfect markers of kidney function because
they are influenced by many renal and nonrenal factors independent of kidney function. A …

There has been intensive effort to identify in vivo biomarkers that can be used to monitor
drug‐induced kidney damage and identify injury before significant impairment occurs …

Earlier and more reliable detection of drug-induced kidney injury would improve clinical care
and help to streamline drug-development. As the current standards to monitor renal function …

A host of novel renal biomarkers have been developed over the past few decades which
have enhanced monitoring of renal disease and drug-induced kidney injury in both …

Several novel urinary kidney biomarkers were recently approved by the US-FDA and EMA
for improved detection of nephrotoxicity, but few data regarding their performance are …

The detection of acute kidney injury (AKI) and the monitoring of chronic kidney disease
(CKD) is becoming more important in industrialized countries. Because of the direct relation …

Nephrotoxicity occurs when kidney-specific detoxification and excretion do not work properly
due to the damage or destruction of kidney function by exogenous or endogenous toxicants …

Since nephrotoxicity affects the development of drug candidates, it is important to detect their
toxicity at an early stage of drug development. In this study, we measured twelve urinary …

Context. A broad range of drugs and chemicals are capable of evoking acute kidney injury,
which is conventionally determined by rising serum creatinine concentrations. However …

The kidney is one of the main targets of drug toxicity, but early detection of renal damage is
often difficult. As part of the InnoMed PredTox project, a collaborative effort aimed at …