In addition to their bioenergetic intracellular function, several classical metabolites act as
extracellular signaling molecules activating cell-surface G-protein-coupled receptors …

Increasing evidence has indicated that diet and metabolites, including bacteria-and host-
derived metabolites, orchestrate host pathophysiology by regulating metabolism, immune …

Nutrition and the gut microbiome regulate many systems, including the immune, metabolic,
and nervous systems. We propose that the host responds to deficiency (or sufficiency) of …

Several G protein-coupled receptors (GPCRs) that are activated by intermediates of energy
metabolism—such as fatty acids, saccharides, lactate and ketone bodies—have recently …

The incidence of obesity and type 2 diabetes (T2D) has been increasing steadily worldwide.
It is estimated that by 2045 more than 800 million people will be suffering from diabetes …

The human body contains thousands of metabolites derived from mammalian cells, the
microbiota, food, and medical drugs. Many bioactive metabolites act through the …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
signaling molecules and regulate a host of physiological and disease processes. To better …

G-protein coupled receptors (GPCRs) are involved in the regulation of adipose tissue
function, but the total number of GPCRs expressed by human subcutaneous adipose tissue …

Diet and gut microbial metabolites mediate host immune responses and are central to the
maintenance of intestinal health. The metabolite-sensing G-protein coupled receptors …

The prevalence of obesity and type 2 diabetes (T2D) is increasing worldwide, and these two
metabolic disorders are closely linked. Lifestyle modification, including weight loss and …