DNA methylation variability arises due to concurrent genetic and environmental influences.
Each of them is a mixture of regular and noisy sources, whose relative contribution has not …

Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …

Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

Although DNA methylation data yields highly accurate age predictors, little is known about
the dynamics of this quintessential epigenomic biomarker during lifespan. To narrow the …

DNA methylation is a key epigenetic process which has been intimately associated with
gene regulation. In recent years growing evidence has associated DNA methylation status …

DNA methylation (DNAm) overwrites information about multiple extrinsic factors on the
genome. Age is one of these factors. Age causes characteristic DNAm changes that are …

Age-related changes in DNA methylation (DNAm) form the basis of the most robust
predictors of age—epigenetic clocks—but a clear mechanistic understanding of exactly …

Background Aging affects the incidence of diseases such as cancer and dementia, so the
development of biomarkers for aging is an important research topic in medical science …

DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …